Proteintech

SLC25A46 Polyclonal Antibody

FIGURE: 1 / 1

SLC25A46 Antibody (12277-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 12277-1-AP (SLC25A46 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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Product Details

12277-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,500

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLC25A46 Fusion Protein Ag2923

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

333 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

SLC25A46 belongs to the SLC25 family of mitochondrial carrier proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells.

Journal of cell science

Santo-Domingo J,Lassueur S,Galindo AN,Alvarez-Illera P,Romero-Sanz S,Caldero-Escudero E,de la Fuente S,Dayon L,Wiederkehr A

Sat Apr 15 00:00:00 UTC 2023

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.

Science advances

Antico O,Ordureau A,Stevens M,Singh F,Nirujogi RS,Gierlinski M,Barini E,Rickwood ML,Prescott A,Toth R,Ganley IG,Harper JW,Muqit MMK

Fri Nov 12 00:00:00 UTC 2021

Reanalysis of Exome Data Identifies Novel SLC25A46 Variants Associated with Leigh Syndrome.

Journal of personalized medicine

Li Q,Madden JA,Lin J,Shi J,Rosen SM,Schmitz-Abe K,Agrawal PB

Thu Dec 02 00:00:00 UTC 2021

A High-Density Human Mitochondrial Proximity Interaction Network.

Cell metabolism

Antonicka H,Lin ZY,Janer A,Aaltonen MJ,Weraarpachai W,Gingras AC,Shoubridge EA

Tue Sep 01 00:00:00 UTC 2020

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.

Molecular biology of the cell

Steffen J,Vashisht AA,Wan J,Jen JC,Claypool SM,Wohlschlegel JA,Koehler CM

Wed Mar 01 00:00:00 UTC 2017

SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.

EMBO molecular medicine

Janer A,Prudent J,Paupe V,Fahiminiya S,Majewski J,Sgarioto N,Des Rosiers C,Forest A,Lin ZY,Gingras AC,Mitchell G,McBride HM,Shoubridge EA

Thu Sep 01 00:00:00 UTC 2016

Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.

Brain : a journal of neurology

Wan J,Steffen J,Yourshaw M,Mamsa H,Andersen E,Rudnik-Schöneborn S,Pope K,Howell KB,McLean CA,Kornberg AJ,Joseph J,Lockhart PJ,Zerres K,Ryan MM,Nelson SF,Koehler CM,Jen JC

Tue Nov 01 00:00:00 UTC 2016

Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.

Brain : a journal of neurology

Wan J,Steffen J,Yourshaw M,Mamsa H,Andersen E,Rudnik-Schöneborn S,Pope K,Howell KB,McLean CA,Kornberg AJ,Joseph J,Lockhart PJ,Zerres K,Ryan MM,Nelson SF,Koehler CM,Jen JC

Tue Nov 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Mitochondrial outer membrane protein SLC25A46; Solute carrier family 25 member 46; solute carrier family 25, member 46

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Gene Aliases: 1200007B05Rik; AI325987; HMSN6B; RGD1305072; SLC25A46; TB1

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UniProt ID: (Human) Q96AG3, (Mouse) Q9CQS4, (Rat) Q5EB62

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Entrez Gene ID: (Human) 91137, (Mouse) 67453, (Rat) 291709

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Function(s)

protein binding molecular_function

Process(es)

transport mitochondrial membrane fission biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SLC25A46 Polyclonal Antibody

SLC25A46 Antibody (12277-1-AP) in WB

Product Details

12277-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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