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SLC38A3 Polyclonal Antibody

SLC38A3 Antibody in Immunocytochemistry (ICC/IF)

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SLC38A3 Antibody (14315-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HEK-293 cells using 14315-1-AP (SLC38A3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SLC38A3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SLC38A3 Antibody in Flow Cytometry (Flow)

SLC38A3 Antibody in Immunoprecipitation (IP)

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Product Details

14315-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLC38A3 Fusion Protein Ag5553 (1-191 aa encoded by BC042875)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEAPLQTEM VELVPNGKHS EGLLPVITPM AGNQRVEDPA RSCMEGKSFL QKSPSKEPHF TDFEGKTSFG MSVFNLSNAI MGSGILGLAY AMANTGIILF LFLLTAVALL SSYSIHLLLK SSGVVGIRAY EQLGYRAFGT PGKLAAALAI TLQNIGAMSS YLYIIKSELP LVIQTFLNLE EKTSDWYMNG NY (1-191 aa encoded by BC042875)

Target Information

As a sodium-dependent amino acid/proton antiporter, SLC38A3 mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. It also recognizes histidine, asparagine and alanine. It may mediate amino acid transport in either direction under physiological conditions and play a role in nitrogen metabolism and synaptic transmission.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sex Modulates Response to Renal-Tubule-Targeted Insulin Receptor Deletion in Mice.

International journal of molecular sciences

Sohail S,Akkawi G,Rechter T,Fluitt MB,Ecelbarger CM

Sat Apr 29 00:00:00 UTC 2023

Long-term exposure changes the environmentally relevant bis(2-ethylhexyl) phthalate to be a neuro-hazardous substance disrupting neural homeostasis in emotional and cognitive functions.

Environmental pollution (Barking, Essex : 1987)

Kang JS,Baek JH,Song MY,Rehman NU,Chung HJ,Lee DK,Yoo DY,Kim HJ

Mon May 01 00:00:00 UTC 2023

The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.

International journal of molecular sciences

Dąbrowska K,Skowrońska K,Popek M,Albrecht J,Zielińska M

Mon Oct 18 00:00:00 UTC 2021

The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.

International journal of molecular sciences

Dąbrowska K,Skowrońska K,Popek M,Albrecht J,Zielińska M

Mon Oct 18 00:00:00 UTC 2021

The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.

International journal of molecular sciences

Dąbrowska K,Skowrońska K,Popek M,Albrecht J,Zielińska M

Mon Oct 18 00:00:00 UTC 2021

Perturbation of astroglial Slc38 glutamine transporters by NH₄⁺ contributes to neurophysiologic manifestations in acute liver failure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hamdani EH,Popek M,Frontczak-Baniewicz M,Utheim TP,Albrecht J,Zielińska M,Chaudhry FA

Thu Jul 01 00:00:00 UTC 2021

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 UTC 2020

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 UTC 2020

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 UTC 2020

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 UTC 2020

Sexually dimorphic and brain region-specific transporter adaptations in system x_c^- null mice.

Neurochemistry international

Sosnoski HM,Sears SMS,He Y,Frare C,Hewett SJ

Tue Dec 01 00:00:00 UTC 2020

Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Aljaylani A,Fluitt M,Piselli A,Shepard BD,Tiwari S,Ecelbarger CM

Sat Jul 18 00:00:00 UTC 2020

Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex.

Neuroscience

Popek M,Bobula B,Sowa J,Hess G,Frontczak-Baniewicz M,Albrecht J,Zielińska M

Thu Oct 15 00:00:00 UTC 2020

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.

Autophagy

Huang X,Gan G,Wang X,Xu T,Xie W

Mon Jul 01 00:00:00 UTC 2019

Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.

International journal of molecular sciences

Dąbrowska K,Zielińska M

Wed Jan 09 00:00:00 UTC 2019

Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.

International journal of molecular sciences

Dąbrowska K,Zielińska M

Wed Jan 09 00:00:00 UTC 2019

Protein kinase C-mediated impairment of glutamine outward transport and SN1 transporter distribution by ammonia in mouse cortical astrocytes.

Neurochemistry international

Dąbrowska K,Albrecht J,Zielińska M

Sat Sep 01 00:00:00 UTC 2018

Protein kinase C-mediated impairment of glutamine outward transport and SN1 transporter distribution by ammonia in mouse cortical astrocytes.

Neurochemistry international

Dąbrowska K,Albrecht J,Zielińska M

Sat Sep 01 00:00:00 UTC 2018

Ceftriaxone Improves Cognitive Function and Upregulates GLT-1-Related Glutamate-Glutamine Cycle in APP/PS1 Mice.

Journal of Alzheimer's disease : JAD

Fan S,Xian X,Li L,Yao X,Hu Y,Zhang M,Li W

Mon Nov 25 00:00:00 UTC 2019

Ceftriaxone Improves Cognitive Function and Upregulates GLT-1-Related Glutamate-Glutamine Cycle in APP/PS1 Mice.

Journal of Alzheimer's disease : JAD

Fan S,Xian X,Li L,Yao X,Hu Y,Zhang M,Li W

Mon Nov 25 00:00:00 UTC 2019

RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells.

Cancer letters

Wu J,He Z,Yang XM,Li KL,Wang DL,Sun FL

Tue Aug 01 00:00:00 UTC 2017

RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells.

Cancer letters

Wu J,He Z,Yang XM,Li KL,Wang DL,Sun FL

Tue Aug 01 00:00:00 UTC 2017

Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1.

Cancer letters

Wang Y,Fu L,Cui M,Wang Y,Xu Y,Li M,Mi J

Mon May 01 00:00:00 UTC 2017

Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1.

Cancer letters

Wang Y,Fu L,Cui M,Wang Y,Xu Y,Li M,Mi J

Mon May 01 00:00:00 UTC 2017

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.

Journal of neurochemistry

Zielińska M,Dąbrowska K,Hadera MG,Sonnewald U,Albrecht J

Fri Jan 01 00:00:00 UTC 2016

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.

Journal of neurochemistry

Zielińska M,Dąbrowska K,Hadera MG,Sonnewald U,Albrecht J

Fri Jan 01 00:00:00 UTC 2016

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

Journal of neurochemistry

Frigerio F,Karaca M,De Roo M,Mlynárik V,Skytt DM,Carobbio S,Pajęcka K,Waagepetersen HS,Gruetter R,Muller D,Maechler P

Thu Nov 01 00:00:00 UTC 2012

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

Journal of neurochemistry

Frigerio F,Karaca M,De Roo M,Mlynárik V,Skytt DM,Carobbio S,Pajęcka K,Waagepetersen HS,Gruetter R,Muller D,Maechler P

Thu Nov 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: mNAT; N system amino acids transporter NAT-1; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; SLC38A3; slc38a3 {ECO:0000312|RGD:628620}; Sodium-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; solute carrier family 38, member 3; System N amino acid transporter 1; system N1 amino acid transporter; system N1 Na+ and H+-coupled glutamine transporter

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Gene Aliases: 0610012J02Rik; D9Ucla2; G17; mNAT; NAT1; Slc38-3; SLC38A3; SN1; SNAT3

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UniProt ID: (Human) Q99624, (Rat) Q9JHZ9, (Mouse) Q9DCP2

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Entrez Gene ID: (Human) 10991, (Rat) 252919, (Mouse) 76257

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Function(s)

L-histidine transmembrane transporter activity amino acid transmembrane transporter activity L-alanine transmembrane transporter activity L-asparagine transmembrane transporter activity L-glutamine transmembrane transporter activity symporter activity antiporter activity

Process(es)

sodium ion transport amino acid transport asparagine transport glutamine transport brain development female pregnancy L-alanine transport histidine transport cellular response to potassium ion starvation positive regulation of transcription from RNA polymerase II promoter in response to acidic pH L-histidine transmembrane transport positive regulation of glutamine transport amino acid transmembrane transport transport ion transport drug transmembrane transport cation transmembrane transport L-alpha-amino acid transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SLC38A3 Polyclonal Antibody

SLC38A3 Antibody (14315-1-AP) in ICC/IF

Product Details

14315-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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