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SLC39A2 Antibody (PA5-99743) in ICC/IF
Immunofluorescent analysis of SLC39A2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SLC39A2 polyclonal antibody (Product # PA5-99743) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-99743
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC39A2(Accession Q9NP94), corresponding to amino acid residues A14-M64.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818676
Product Specific Information
Antibody detects endogenous levels of total ZIP2.
Target Information
The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 6A1; Eti-1; MGC119190; solute carrier family 39 (zinc transporter), member 2; Solute carrier family 39 member 2; Zinc transporter ZIP2; zinc uptake transporter 2; ZIP-2; Zrt- and Irt-like protein 2
Gene Aliases: 6A1; ETI-1; SLC39A2; ZIP-2; ZIP2
UniProt ID: (Human) Q9NP94
Entrez Gene ID: (Human) 29986
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