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Product Details
PA5-27880
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human SLC4A8. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.99 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2545356
Product Specific Information
Recommended positive controls: IMR32, U87-MG.
Predicted reactivity: Mouse (92%), Rat (91%), Rhesus Monkey (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Electroneutral Na(+)-driven Cl-HCO3 exchanger; Electroneutral sodium bicarbonate exchanger 1; k-NBC3; Solute carrier family 4 member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8
Gene Aliases: KIAA0739; NBC; NBC3; NDCBE; NDCBE1; SLC4A8
UniProt ID: (Human) Q2Y0W8
Entrez Gene ID: (Human) 9498
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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