Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
SLC4A8/SLC4A10 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 2
SLC4A8/SLC4A10 Antibody (PA5-101904) in ICC/IF
Immunocytochemistry analysis of SLC4A8/SLC4A10 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SLC4A8/SLC4A10 polyclonal antibody (Product # PA5-101904) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 co... View More
Product Details
PA5-101904
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC4A8(Accession Q2Y0W8), corresponding to amino acid residues F1040-S1090.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2851336
Product Specific Information
Antibody detects endogenous levels of total SLC4A8/10.
Target Information
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Electroneutral Na(+)-driven Cl-HCO3 exchanger; Electroneutral Na+-driven Cl-HCO3 exchanger; Electroneutral sodium bicarbonate exchanger 1; k-NBC3; Na-driven Cl-HCO3 exchanger NDCBE1-A; Na-driven Cl-HCO3 exchanger NDCBE1-B; Na-driven Cl-HCO3 exchanger NDCBE1-C; slc4a8; slc4a8 {ECO:0000312|RGD:735164}; sodium bicarbonate cotransporter isoform 3 kNBC-3; sodium bicarbonate cotransporter member 10 variant NBCn2-E'; sodium bicarbonate cotransporter NBCn2-E; Sodium-driven chloride bicarbonate exchanger; solute carrier family 4 (anion exchanger), member 8; Solute carrier family 4 member 10; Solute carrier family 4 member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8; solute carrier family 4, sodium bicarbonate cotransporter-like, member 10; solute carrier family 4, sodium bicarbonate transporter, member 10; solute carrier family 4, sodium bicarbonate transporter-like, member 10
Gene Aliases: AW493845; C230026C11; KIAA0739; Kiaa4136; kNBC-3; mKIAA4136; NBC; NBC3; NBCN2; NCBE; NDCBE; NDCBE1; SLC4A10; SLC4A8
UniProt ID: (Human) Q6U841, (Human) Q2Y0W8, (Rat) Q80ZA5, (Mouse) Q5DTL9, (Mouse) Q8JZR6, (Rat) Q6RVG2
Entrez Gene ID: (Human) 57282, (Human) 9498, (Rat) 295645, (Mouse) 94229, (Mouse) 59033, (Rat) 315311
anion transport
regulation of pH
nervous system development
response to light stimulus
post-embryonic development
bicarbonate transport
pyramidal neuron development
regulation of cellular pH
ion transmembrane transport
multicellular organism growth
locomotory exploration behavior
sodium ion transmembrane transport
brain morphogenesis
regulation of intracellular pH
anion transmembrane transport
hydrogen ion transmembrane transport
transport
ion transport
sodium ion transport
embryo development
inorganic anion transport
chloride transport
protein glycosylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support