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Invitrogen
SLC6A11 Polyclonal Antibody
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Product Details
PA5-45004
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human SLC6A11 (aa 577-626).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608709
Product Specific Information
Peptide sequence: EGTLPEKLQK LTTPSTDLKM RGKLGVSPRM VTVNDCDAKL KSDGTIAAIT
Sequence homology: Cow: 85%; Dog: 92%; Guinea Pig: 92%; Horse: 85%; Human: 100%; Mouse: 77%; Rabbit: 93%; Rat: 92%
Target Information
Slc6a11 encode GABA transporters that are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) and mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters have been identified and localized to neurons and glia. The protein encoded by the Slc6a11 gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in the Slc6a11 gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for the Slc6a11 gene. Diseases associated with SLC6A11 include Tricuspid Valve Stenosis and Pulmonary Valve Insufficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA transporter 3; GAT-3; Sodium- and chloride-dependent GABA transporter 3; solute carrier family 6 (neurotransmitter transporter), member 11; solute carrier family 6 (neurotransmitter transporter, GABA), member 11; Solute carrier family 6 member 11
Gene Aliases: GABT3; GAT-3; GAT3; GAT4; SLC6A11
UniProt ID: (Human) P48066
Entrez Gene ID: (Human) 6538
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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