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SLC6A8 Polyclonal Antibody

SLC6A8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SLC6A8 Antibody (20299-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 20299-1-AP) SLC6A8 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

SLC6A8 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

20299-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLC6A8 Fusion Protein Ag14110 (541-635 aa encoded by BC012355)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YYEPLVYNN TYVYPWWGEA MGWAFALSSM LCVPLHLLGC LLRAKGTMAE RWQHLTQPIW GLHHLEYRAQ DADVRGLTTL TPVSESSKVV VVESVM (541-635 aa encoded by BC012355)

Target Information

SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein that belongs to the sodium/neurotransporter (SNF) family. Expressed in a variety of tissues including kidney, skeletal muscle, heart, brain, prostate, testis and colon, SLC6A8 functions to transport creatine into and out of cells, specifically those found in brain and muscle tissue. Creatine, an organic acid, occurs naturally and is essential for supplying the energy needed for proper muscle and nerve function. Defects in the gene encoding SLC6A8 lead to cerebral creatine deficiency and are the cause of X-linked creatine deficiency syndrome, a rare disorder characterized by facial anomalies, seizures and mental retardation. Multiple isoforms of SLC6A8 exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport.

Oncoimmunology

Tian C,Yuan H,Lu Y,He H,Li Q,Li S,Yang J,Wang M,Xu R,Liu Q,Xiang M

Tue Apr 25 00:00:00 UTC 2023

Long Non-Coding RNA AL513318.2 as ceRNA Binding to hsa-miR-26a-5p Upregulates SLC6A8 Expression and Predicts Poor Prognosis in Non-Small Lung Cancer.

Frontiers in oncology

Fan Y,Zhou Y,Li X,Lou M,Gao Z,Tong J,Yuan K

Mon May 02 00:00:00 UTC 2022

SLC6A8 is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma.

Frontiers in genetics

Fan Y,Zhou Y,Lou M,Gao Z,Li X,Yuan K

Sat Jul 16 00:00:00 UTC 2022

SLC6A8 is involved in the progression of non-small cell lung cancer through the Notch signaling pathway.

Annals of translational medicine

Feng Y,Guo X,Tang H

Mon Feb 01 00:00:00 UTC 2021

SLC6A8 is involved in the progression of non-small cell lung cancer through the Notch signaling pathway.

Annals of translational medicine

Feng Y,Guo X,Tang H

Mon Feb 01 00:00:00 UTC 2021

Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathway.

Journal of agricultural and food chemistry

Nishikawa S,Hydo T,Aoyama H,Miyata R,Kumazawa S,Tsuda T

Wed Jan 29 00:00:00 UTC 2020

SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells.

Technology in cancer research & treatment

Yuan L,Wu XJ,Li WC,Zhuo C,Xu Z,Tan C,Ma R,Wang J,Pu J

Mon Nov 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: creatine transporter 1; creatine transporter SLC6A8 variant D; creatine transporter, solute carrier family 6, member 8; CT1; MGC87396; Sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Solute carrier family 6 member 8; solute carrier family 6, member 8

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Gene Aliases: AA589632; CCDS1; Creat; CRT; CRTR; CT1; CTR5; SLC6A8

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UniProt ID: (Human) P48029, (Mouse) Q8VBW1

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Entrez Gene ID: (Human) 6535, (Mouse) 102857

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Function(s)

molecular_function creatine transmembrane transporter activity creatine:sodium symporter activity neurotransmitter:sodium symporter activity choline transmembrane transporter activity symporter activity

Process(es)

creatine metabolic process transport neurotransmitter transport muscle contraction biological_process creatine transport sodium ion transmembrane transport creatine transmembrane transport ion transport sodium ion transport organic cation transport choline transport cofactor transport ammonium transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SLC6A8 Polyclonal Antibody

SLC6A8 Antibody (20299-1-AP) in IHC (P)

Product Details

20299-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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