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Invitrogen
SLC9A7 Polyclonal Antibody
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FIGURE: 1 / 2
SLC9A7 Antibody (PA5-106748) in ICC/IF
Immunocytochemistry analysis of SLC9A7 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SLC9A7 polyclonal antibody (Product # PA5-106748) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-106748
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC9A7(Accession Q96T83), corresponding to amino acid residues L535-A585.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854416
Product Specific Information
Antibody detects endogenous levels of total SLC9A7.
Target Information
Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of N+ and H+ ions in various tissues. The NHE catalyzes the electroneural transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH (pHi) in addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. At least 7 NHE isoforms (NHE1-7) have been cloned so far. They are all similar in their primary structure and predicted to have 10-12 transmembrane domains. The C-terminal domain of NHEs are predicted to be intracellular. NHE7 (human 725 aa, chromosome Xp11.4) is ubiquitously expressed, and predominantly localizes to the trans-golgi network. NHE7 mediates the influx of Na+ or K+ in exchange for H+. It is ~70% related to NHE6 but relatively less (~25%) homologous with other NHEs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)/H(+) exchanger 7; NHE-7; nonselective sodium potassium/proton exchanger; Sodium/hydrogen exchanger 7; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7; solute carrier family 9 (sodium/hydrogen exchanger), member 7; Solute carrier family 9 member 7; solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
Gene Aliases: A530087D17Rik; NHE-7; NHE7; SLC9A6; SLC9A7
UniProt ID: (Human) Q96T83, (Mouse) Q8BLV3
Entrez Gene ID: (Human) 84679, (Mouse) 236727, (Rat) 317170
ion transport
regulation of pH
regulation of intracellular pH
potassium ion transmembrane transport
sodium ion import across plasma membrane
hydrogen ion transmembrane transport
transport
cation transport
potassium ion transport
sodium ion transport
sodium ion transmembrane transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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