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Proteintech
SLIT2 Polyclonal Antibody
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Product Details
20217-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to SLIT2.
Target Information
SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; Slit homolog 2 protein; Slit-2
Gene Aliases: Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2; SLIT2
UniProt ID: (Human) O94813, (Mouse) Q9R1B9
Entrez Gene ID: (Human) 9353, (Rat) 360272, (Mouse) 20563
GTPase inhibitor activity
calcium ion binding
protein binding
heparin binding
identical protein binding
protein homodimerization activity
laminin-1 binding
proteoglycan binding
heparan sulfate proteoglycan binding
Roundabout binding
follicle-stimulating hormone receptor activity
chemorepellent activity
receptor binding
ureteric bud development
negative regulation of protein phosphorylation
cell migration involved in sprouting angiogenesis
negative regulation of leukocyte chemotaxis
axon guidance
motor neuron axon guidance
negative regulation of lamellipodium assembly
negative regulation of endothelial cell migration
negative regulation of smooth muscle cell migration
spinal cord development
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
chemorepulsion involved in postnatal olfactory bulb interneuron migration
corticospinal neuron axon guidance through spinal cord
negative regulation of cell growth
negative regulation of cell migration
negative regulation of actin filament polymerization
retinal ganglion cell axon guidance
response to nutrient levels
cellular response to hormone stimulus
negative regulation of GTPase activity
Roundabout signaling pathway
positive regulation of apoptotic process
negative regulation of vascular permeability
branching morphogenesis of an epithelial tube
axon extension involved in axon guidance
negative regulation of inflammatory response
positive regulation of axonogenesis
negative chemotaxis
induction of negative chemotaxis
negative regulation of small GTPase mediated signal transduction
response to cortisol
apoptotic process involved in luteolysis
negative regulation of chemokine-mediated signaling pathway
cellular response to heparin
negative regulation of smooth muscle cell chemotaxis
negative regulation of mononuclear cell migration
negative regulation of neutrophil chemotaxis
negative regulation of monocyte chemotaxis
negative regulation of retinal ganglion cell axon guidance
negative regulation of cellular response to growth factor stimulus
metanephros development
in utero embryonic development
chemotaxis
axonogenesis
brain development
negative regulation of cell proliferation
negative regulation of gene expression
single organismal cell-cell adhesion
olfactory bulb development
telencephalon cell migration
cell differentiation
negative regulation of axon extension
dorsal/ventral axon guidance
follicle-stimulating hormone signaling pathway
negative regulation of catalytic activity
neuron projection morphogenesis
mammary gland duct morphogenesis
mammary duct terminal end bud growth
multicellular organism development
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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