Proteintech

SLN Polyclonal Antibody

SLN Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

SLN Antibody (18395-1-AP) in ICC/IF

Immunofluorescent analysis of PC-3 cells using 18395-1-AP (SLN antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SLN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

18395-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLN Fusion Protein Ag13176 (1-31 aa encoded by BC005261)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.65 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognize the 4 kDa band in Human heart and skeletal muscle.

Immunogen sequence: MGINTRELF LNFTIVLITV ILMWLLVRSY QY (1-31 aa encoded by BC005261)

Target Information

SLN, also named as Sarcolipin, belongs to the sarcolipin family. It is associated with calcium ATPase SERCA1. It inhibits SERCA pumps. SLN, a key regulator of cardiac sarco (endo)plasmic reticulum (SR) Ca(2+) ATPase, is predominantly expressed in atria and mediates beta-adrenergic responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Skeletal muscle overexpression of sAnk1.5 in transgenic mice does not predispose to type 2 diabetes.

Scientific reports

Pierantozzi E,Raucci L,Buonocore S,Rubino EM,Ding Q,Laurino A,Fiore F,Soldaini M,Chen J,Rossi D,Vangheluwe P,Chen H,Sorrentino V

Sat May 20 00:00:00 UTC 2023

Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling.

EBioMedicine

Son JS,Chae SA,Zhao L,Wang H,de Avila JM,Zhu MJ,Jiang Z,Du M

Tue Feb 01 00:00:00 UTC 2022

ChREBP-β regulates thermogenesis in brown adipose tissue.

The Journal of endocrinology

Wei C,Ma X,Su K,Qi S,Zhu Y,Lin J,Wang C,Yang R,Chen X,Wang W,Zhang WJ

Mon Jun 01 00:00:00 UTC 2020

Effect of sarcolipin-mediated cell transdifferentiation in sarcopenia-associated skeletal muscle fibrosis.

Experimental cell research

Chen QN,Fan Z,Lyu AK,Wu J,Guo A,Yang YF,Chen JL,Xiao Q

Wed Apr 01 00:00:00 UTC 2020

A Temporal Examination of Cytoplasmic Ca^{2 +} Levels, Sarcoplasmic Reticulum Ca^{2 +} Levels, and Ca^{2 +} -Handling-Related Proteins in Different Skeletal Muscles of Hibernating Daurian Ground Squirrels.

Frontiers in physiology

Wang Z,Zhang J,Ma XF,Chang H,Peng X,Xu SH,Wang HP,Gao YF

Tue Nov 17 00:00:00 UTC 2020

Frontiers in physiology

Wang Z,Zhang J,Ma XF,Chang H,Peng X,Xu SH,Wang HP,Gao YF

Tue Nov 17 00:00:00 UTC 2020

Sarcolipin expression is repressed by endoplasmic reticulum stress in C2C12 myotubes.

Journal of physiology and biochemistry

Takahashi N,Kimura AP,Naito S,Yoshida M,Kumano O,Suzuki T,Itaya S,Moriya M,Tsuji M,Ieko M

Wed Nov 01 00:00:00 UTC 2017

Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA1).

The Journal of biological chemistry

Desmond PF,Labuza A,Muriel J,Markwardt ML,Mancini AE,Rizzo MA,Bloch RJ

Fri Jun 30 00:00:00 UTC 2017

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

Skeletal muscle

Lee CS,Dagnino-Acosta A,Yarotskyy V,Hanna A,Lyfenko A,Knoblauch M,Georgiou DK,Poché RA,Swank MW,Long C,Ismailov II,Lanner J,Tran T,Dong K,Rodney GG,Dickinson ME,Beeton C,Zhang P,Dirksen RT,Hamilton SL

Thu Feb 26 00:00:00 UTC 2015

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

Skeletal muscle

Thu Feb 26 00:00:00 UTC 2015

Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.

The Journal of biological chemistry

Desmond PF,Muriel J,Markwardt ML,Rizzo MA,Bloch RJ

Fri Nov 13 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Sarcolipin

View more View less

Gene Aliases: 2310045A07Rik; SLN

View more View less

UniProt ID: (Human) O00631, (Rat) Q6SLE7, (Mouse) Q9CQD6

View more View less

Entrez Gene ID: (Human) 6588, (Rat) 367086, (Mouse) 66402

View more View less

Function(s)

enzyme inhibitor activity protein binding ATPase binding enzyme regulator activity

Process(es)

regulation of calcium ion transport sarcoplasmic reticulum calcium ion transport regulation of relaxation of muscle regulation of calcium-transporting ATPase activity calcium ion transport negative regulation of catalytic activity negative regulation of protein complex disassembly negative regulation of calcium ion import negative regulation of calcium ion transmembrane transporter activity negative regulation of calcium ion binding positive regulation of protein depolymerization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SLN Polyclonal Antibody

SLN Antibody (18395-1-AP) in ICC/IF

Product Details

18395-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!