Product References
Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication.
PLoS pathogens
Hargest V,Bub T,Neale G,Schultz-Cherry S
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunocytochemistry
Fri Apr 01 00:00:00 UTC 2022
In Vitro Characterization of 177Lu-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer.
Frontiers in oncology
Mohajershojai T,Jha P,Boström A,Frejd FY,Yazaki PJ,Nestor M
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Sat Jul 16 00:00:00 UTC 2022
Epstein-Barr virus nuclear antigen 3C (EBNA3C) interacts with the metabolism sensing C-terminal binding protein (CtBP) repressor to upregulate host genes.
PLoS pathogens
Ohashi M,Hayes M,McChesney K,Johannsen E
51-1500 was used in Western Blot to suggest that CtBP is bound to these promoters in the absence of EBNA3C and that EBNA3C interaction with CtBP interferes with the repressive function of CtBP, leading to EBNA3C mediated upregulation.
Mon Mar 01 00:00:00 UTC 2021
Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia.
Frontiers in endocrinology
Brkić J,Dunk C,Shan Y,O'Brien JA,Lye P,Qayyum S,Yang P,Matthews SG,Lye SJ,Peng C
51-1500 was used in Western Blotting to suggest that Smad2 and Smad3 have opposite functions in the acquisition of an enEVT-like phenotype and defects in Smad3 activation are associated with PE.
Fri May 28 00:00:00 UTC 2021
Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia.
Frontiers in endocrinology
Brkić J,Dunk C,Shan Y,O'Brien JA,Lye P,Qayyum S,Yang P,Matthews SG,Lye SJ,Peng C
51-1500 was used in Western Blotting to suggest that Smad2 and Smad3 have opposite functions in the acquisition of an enEVT-like phenotype and defects in Smad3 activation are associated with PE.
Fri May 28 00:00:00 UTC 2021
Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Journal of cellular and molecular medicine
Ni J,Yang F,Huang XR,Meng J,Chen J,Bader M,Penninger JM,Fung E,Yu XQ,Lan HY
51-1500 was used in Western Blotting to conclude that ACE2 and Mas play an additive protective role in Ang II-induced hypertension and hypertensive nephropathy.
Sun Nov 01 00:00:00 UTC 2020
Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Journal of cellular and molecular medicine
Ni J,Yang F,Huang XR,Meng J,Chen J,Bader M,Penninger JM,Fung E,Yu XQ,Lan HY
51-1500 was used in Western Blotting to conclude that ACE2 and Mas play an additive protective role in Ang II-induced hypertension and hypertensive nephropathy.
Sun Nov 01 00:00:00 UTC 2020
Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction.
BioMed research international
Kim IY,Lee MY,Park MW,Seong EY,Lee DW,Lee SB,Bae SS,Kim SS,Song SH
51-1500 was used in Western Blotting to show renal fibrosis can be promoted by Akt1 deletion by induction of the TGFβ1/STAT3 pathway.
Fri May 07 00:00:00 UTC 2021
Treatment of Hypertensive Heart Disease by Targeting Smad3 Signaling in Mice.
Molecular therapy. Methods & clinical development
Meng J,Qin Y,Chen J,Wei L,Huang XR,Yu X,Lan HY
51-1500 was used in Western Blotting to demonstrate that targeting Smad3 signaling with SIS3 may be a novel and effective therapy for chronic heart disease.
Fri Sep 11 00:00:00 UTC 2020
Treatment of Hypertensive Heart Disease by Targeting Smad3 Signaling in Mice.
Molecular therapy. Methods & clinical development
Meng J,Qin Y,Chen J,Wei L,Huang XR,Yu X,Lan HY
51-1500 was used in Western Blotting to demonstrate that targeting Smad3 signaling with SIS3 may be a novel and effective therapy for chronic heart disease.
Fri Sep 11 00:00:00 UTC 2020
Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer.
Scientific reports
Oh S,Shin S,Song H,Grande JP,Janknecht R
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunohistochemistry
Mon Jun 03 00:00:00 UTC 2019
Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer.
Scientific reports
Oh S,Shin S,Song H,Grande JP,Janknecht R
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunohistochemistry
Mon Jun 03 00:00:00 UTC 2019
Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis.
International journal of cell biology
Devocelle A,Lecru L,François H,Desterke C,Gallerne C,Eid P,Estelle O,Azzarone B,Giron-Michel J
51-1500 was used in Western Blotting to analyse whether human chronic inflammatory nephropathies evolving towards fibrosis could be also characterized by a weak intrarenal IL-15 expression and if IL-15 could inhibit epithelial-mesenchymal transition (EMT) and excess matrix deposition in human renal proximal tubular epithelial cells (RPTEC).
Wed Sep 30 00:00:00 UTC 2020
TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis.
Molecular therapy : the journal of the American Society of Gene Therapy
Feng M,Tang PM,Huang XR,Sun SF,You YK,Xiao J,Lv LL,Xu AP,Lan HY
51-1500 was used in Western Blotting to identify that Erbb4-IR is a novel lncRNA responsible for TGF-Β/Smad3-mediated renal fibrosis by downregulating Smad7.
Wed Jan 03 00:00:00 UTC 2018
miR‑127 aggravates myocardial failure by promoting the TGF‑β1/Smad3 signaling.
Molecular medicine reports
Xu H,Li F
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunofluorescence
Sat Dec 01 00:00:00 UTC 2018
miR‑127 aggravates myocardial failure by promoting the TGF‑β1/Smad3 signaling.
Molecular medicine reports
Xu H,Li F
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunofluorescence
Sat Dec 01 00:00:00 UTC 2018
miR‑127 aggravates myocardial failure by promoting the TGF‑β1/Smad3 signaling.
Molecular medicine reports
Xu H,Li F
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunofluorescence
Sat Dec 01 00:00:00 UTC 2018
TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
International journal of stem cells
Albers RE,Selesniemi K,Natale DRC,Brown TL
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Wed May 30 00:00:00 UTC 2018
Inhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells.
Cell cycle (Georgetown, Tex.)
Thomas AL,Lind H,Hong A,Dokic D,Oppat K,Rosenthal E,Guo A,Thomas A,Hamden R,Jeruss JS
51-1500 was used in Western Blotting to study the effects of the Pin1-Smad3 interaction on TGFβ signalling and breast cancer progression.
Thu Aug 03 00:00:00 UTC 2017
Granulosa Cell Tumors: Novel Predictors of Recurrence in Early-stage Patients.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Sakr S,Abdulfatah E,Thomas S,Al-Wahab Z,Beydoun R,Morris R,Ali-Fehmi R,Bandyopadhyay S
51-1500 was used in Immunohistochemistry on paraffin embedded tissues to evaluate novel predictors of recurrence in granulosa cell tumours from a large single institution cohort.
Mon May 01 00:00:00 UTC 2017
Granulosa Cell Tumors: Novel Predictors of Recurrence in Early-stage Patients.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Sakr S,Abdulfatah E,Thomas S,Al-Wahab Z,Beydoun R,Morris R,Ali-Fehmi R,Bandyopadhyay S
51-1500 was used in Immunohistochemistry on paraffin embedded tissues to evaluate novel predictors of recurrence in granulosa cell tumours from a large single institution cohort.
Mon May 01 00:00:00 UTC 2017
Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol.
Scientific reports
Zhu Y,Takayama T,Wang B,Kent A,Zhang M,Binder BY,Urabe G,Shi Y,DiRenzo D,Goel SA,Zhou Y,Little C,Roenneburg DA,Shi XD,Li L,Murphy WL,Kent KC,Ke J,Guo LW
511500 was used in western blot to study the effects of periadventitial delivery of resveratrol on three major pro-restenotic pathologies
Mon Feb 06 00:00:00 UTC 2017
Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts.
Scientific reports
Chowdhury A,Hasselbach L,Echtermeyer F,Jyotsana N,Theilmeier G,Herzog C
511500 was used in immunocytochemistry and western blot to find that fibulin-6 knockdown fibroblasts affect TGF-beta dependent migration, stress fiber formation, cellular networking, and fibroblast wound contraction
Fri Feb 17 00:00:00 UTC 2017
Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts.
Scientific reports
Chowdhury A,Hasselbach L,Echtermeyer F,Jyotsana N,Theilmeier G,Herzog C
511500 was used in immunocytochemistry and western blot to find that fibulin-6 knockdown fibroblasts affect TGF-beta dependent migration, stress fiber formation, cellular networking, and fibroblast wound contraction
Fri Feb 17 00:00:00 UTC 2017
Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer.
Oncotarget
Lefort K,Ostano P,Mello-Grand M,Calpini V,Scatolini M,Farsetti A,Dotto GP,Chiorino G
511500 was used in western blot to discuss the role of Notch1 in prostate cancer
Tue Jul 26 00:00:00 UTC 2016
Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer.
Oncotarget
Lefort K,Ostano P,Mello-Grand M,Calpini V,Scatolini M,Farsetti A,Dotto GP,Chiorino G
511500 was used in western blot to discuss the role of Notch1 in prostate cancer
Tue Jul 26 00:00:00 UTC 2016
Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Borgogna C,Lanfredini S,Peretti A,De Andrea M,Zavattaro E,Colombo E,Quaglia M,Boldorini R,Miglio U,Doorbar J,Bavinck JN,Quint KD,de Koning MN,Landolfo S,Gariglio M
51-1500 was used in immunocytochemistry to test if beta-HPV gene products are present in lesions from kidney transplant recipients
Fri Aug 01 00:00:00 UTC 2014
The inhibin/activin signalling pathway in human gonadal and adrenal cancers.
Molecular human reproduction
Marino FE,Risbridger G,Gold E
51-1500 was used in immunohistochemistry to examine the mechanism of the inhibin and activin signalling pathway in cancers
Mon Dec 01 00:00:00 UTC 2014
CEACAM1 long cytoplasmic domain isoform is associated with invasion and recurrence of hepatocellular carcinoma.
Annals of surgical oncology
Kiriyama S,Yokoyama S,Ueno M,Hayami S,Ieda J,Yamamoto N,Yamaguchi S,Mitani Y,Nakamura Y,Tani M,Mishra L,Shively JE,Yamaue H
51-1500 was used in immunocytochemistry to examine the association between CEACAM1 isoform balance and hepatocellular carcinoma malignant potential and investigate the molecular interaction between CEACAM1 and beta2SP
Mon Dec 01 00:00:00 UTC 2014
TGF-β induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways.
American journal of clinical and experimental urology
Strand DW,Liang YY,Yang F,Barron DA,Ressler SJ,Schauer IG,Feng XH,Rowley DR
51-1500 was used in western blot to determine how TGF-beta1-induced FGF-2 expression is regulated in prostate stromal fibroblasts and mouse embryo fibroblasts null for Smad2 and Smad3
Thu Nov 06 00:00:00 UTC 2014
FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells.
PloS one
Anttonen M,Pihlajoki M,Andersson N,Georges A,L'hôte D,Vattulainen S,Färkkilä A,Unkila-Kallio L,Veitia RA,Heikinheimo M
51-1500 was used in immunohistochemistry and western blot to examine the molecular interactions of FOXL2, GATA4, and SMAD3 and their roles in CCND2 regulation.
Mon Sep 08 00:00:00 UTC 2014
FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells.
PloS one
Anttonen M,Pihlajoki M,Andersson N,Georges A,L'hôte D,Vattulainen S,Färkkilä A,Unkila-Kallio L,Veitia RA,Heikinheimo M
51-1500 was used in immunohistochemistry and western blot to examine the molecular interactions of FOXL2, GATA4, and SMAD3 and their roles in CCND2 regulation.
Mon Sep 08 00:00:00 UTC 2014
FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells.
PloS one
Anttonen M,Pihlajoki M,Andersson N,Georges A,L'hôte D,Vattulainen S,Färkkilä A,Unkila-Kallio L,Veitia RA,Heikinheimo M
51-1500 was used in immunohistochemistry and western blot to examine the molecular interactions of FOXL2, GATA4, and SMAD3 and their roles in CCND2 regulation.
Mon Sep 08 00:00:00 UTC 2014
Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Nature structural & molecular biology
Patrick AN,Cabrera JH,Smith AL,Chen XS,Ford HL,Zhao R
51-1500 was used in western blot to report the 2.0-Å structure of SIX bound to EYA2.
Mon Apr 01 00:00:00 UTC 2013
Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury.
Journal of the American Society of Nephrology : JASN
Chai Z,Dai A,Tu Y,Li J,Wu T,Wang Y,Hale LJ,Koentgen F,Thomas MC,Cooper ME
51-1500 was used in immunohistochemistry to study the role of cell division autoantigen 1 in diabetes-associated renal injury
Fri Nov 01 00:00:00 UTC 2013
Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD.
American journal of physiology. Lung cellular and molecular physiology
Brandsma CA,Timens W,Jonker MR,Rutgers B,Noordhoek JA,Postma DS
Tue Oct 15 00:00:00 UTC 2013
Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD.
American journal of physiology. Lung cellular and molecular physiology
Brandsma CA,Timens W,Jonker MR,Rutgers B,Noordhoek JA,Postma DS
Tue Oct 15 00:00:00 UTC 2013
Alterations of Smad expression and activation in defining 2 subtypes of human head and neck squamous cell carcinoma.
Head & neck
Xie W,Aisner S,Baredes S,Sreepada G,Shah R,Reiss M
51-1500 was used in immunohistochemistry - paraffin section to test if disruptions of transforming growth factor-beta/Smad signaling contribute to the development of head and neck squamous cell carcinoma.
Tue Jan 01 00:00:00 UTC 2013
Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness.
Pathology, research and practice
Parviainen H,Schrade A,Kiiveri S,Prunskaite-Hyyryläinen R,Haglund C,Vainio S,Wilson DB,Arola J,Heikinheimo M
51-1500 was used in immunohistochemistry to study the expression and prognostic value of Wnt and TGF-? pathway components and key adrenal transcription factors in adrenocortical tumors
Thu Aug 01 00:00:00 UTC 2013
A dynein motor attachment complex regulates TGFß/Smad3 signaling.
International journal of biological sciences
Jin Q,Gao G,Mulder KM
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Wed Jan 22 00:00:00 UTC 2014
Transforming growth factor-β1 (TGF-β1) regulates cell junction restructuring via Smad-mediated repression and clathrin-mediated endocytosis of nectin-like molecule 2 (Necl-2).
PloS one
Gao Y,Lui WY
51-1500 was used in western blot to determine how TGF-β regulates Necl-2 expression during spermatogenesis.
Tue Feb 18 00:00:00 UTC 2014
Transforming growth factor-β1 (TGF-β1) regulates cell junction restructuring via Smad-mediated repression and clathrin-mediated endocytosis of nectin-like molecule 2 (Necl-2).
PloS one
Gao Y,Lui WY
51-1500 was used in western blot to determine how TGF-β regulates Necl-2 expression during spermatogenesis.
Tue Feb 18 00:00:00 UTC 2014
TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition.
Cell reports
Stankic M,Pavlovic S,Chin Y,Brogi E,Padua D,Norton L,Massagué J,Benezra R
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Thu Dec 12 00:00:00 UTC 2013
Intense pulsed light enhances transforming growth factor beta1/Smad3 signaling in acne-prone skin.
Journal of cosmetic dermatology
Ali MM,Porter RM,Gonzalez ML
51-1500 was used in Immunohistochemistry-immunofluorescence to conclude that intense pulsed light upregulates TGF-β1/Smad3 signaling in perilesional skin obtained from patients with mild-to-moderate inflammatory acne vulgaris.
Sun Sep 01 00:00:00 UTC 2013
Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.
Molecular cancer research : MCR
Chen G,Ghosh P,Longo DL
51-1500 was used in western blot to report a novel mechanism by which cells become resistant to TGF-beta-mediated growth suppression
Sat Jan 01 00:00:00 UTC 2011
Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.
The Journal of biological chemistry
Hong M,Wilkes MC,Penheiter SG,Gupta SK,Edens M,Leof EB
51-1500 was used in western blot to investigate the role of nonreceptor tyrosine focal adhesion kinase TGF-beta signaling.
Fri May 20 00:00:00 UTC 2011
Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers.
Cancer research
Li Y,Cao H,Jiao Z,Pakala SB,Sirigiri DN,Li W,Kumar R,Mishra L
51-1500 was used in immunocytochemistry and western blot to report that carcinoembryonic antigen directly interacts with TGF-beta receptor and inhibits TGF-beta signaling
Fri Oct 15 00:00:00 UTC 2010
Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics.
Oncogene
Garamszegi N,Garamszegi SP,Samavarchi-Tehrani P,Walford E,Schneiderbauer MM,Wrana JL,Scully SP
51-1500 was used in western blot to elucidate TGF-beta receptor dynamics and consequential signaling
Thu Apr 22 00:00:00 UTC 2010
Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.
International journal of cancer
Fukasawa H,Yamamoto T,Fujigaki Y,Misaki T,Ohashi N,Takayama T,Suzuki S,Mugiya S,Oda T,Uchida C,Kitagawa K,Hattori T,Hayashi H,Ozono S,Kitagawa M,Hishida A
51-1500 was used in western blot to study transforming growth factor-beta signaling in renal cell carcinoma
Fri Oct 01 00:00:00 UTC 2010
Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.
The American journal of pathology
Luo DD,Phillips A,Fraser D
51-1500 was used in EMSA to study the effect of BMP-7 on TGF-beta treated proximal tubular cells
Mon Mar 01 00:00:00 UTC 2010
Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.
The American journal of pathology
Luo DD,Phillips A,Fraser D
51-1500 was used in EMSA to study the effect of BMP-7 on TGF-beta treated proximal tubular cells
Mon Mar 01 00:00:00 UTC 2010
Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.
The American journal of pathology
Luo DD,Phillips A,Fraser D
51-1500 was used in EMSA to study the effect of BMP-7 on TGF-beta treated proximal tubular cells
Mon Mar 01 00:00:00 UTC 2010
Fuzheng Huayu recipe and vitamin E reverse renal interstitial fibrosis through counteracting TGF-beta1-induced epithelial-to-mesenchymal transition.
Journal of ethnopharmacology
Wang QL,Yuan JL,Tao YY,Zhang Y,Liu P,Liu CH
51-1500 was used in immunocytochemistry and western blot to determine the mechanism of action of Fuzheng Huayu recipe and vitamin E against renal interstitial fibrosis related to transforming growth factor-beta1-mediated tubular epithelial-to-mesenchymal
Wed Feb 17 00:00:00 UTC 2010
SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.
Cell cycle (Georgetown, Tex.)
Lin Q,Chen D,Timchenko NA,Medrano EE
51-1500 was used in western blot to discuss how SKI-mediated processes in melanoma cells
Sat May 01 00:00:00 UTC 2010
SMAD3 and EGR1 physically and functionally interact in promoter-specific fashion.
Cellular signalling
Fortin J,Bernard DJ
51-1500 was used in western blot to elucidate the species-specific modulation of the GNRH1 response by activin signaling
Tue Jun 01 00:00:00 UTC 2010
Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
Molecular biology of the cell
Moyano JV,Greciano PG,Buschmann MM,Koch M,Matlin KS
51-1500 was used in western blot to examine production and localization of LM-332 in epithelial cells
Mon Nov 01 00:00:00 UTC 2010
Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro.
BMC cell biology
Wang QL,Tao YY,Yuan JL,Shen L,Liu CH
51-1500 was used in western blot to elucidate the mechanism by which salvianolic Acid B modulates the epithelial-to-mesenchymal transition
Wed May 05 00:00:00 UTC 2010
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry
Bergström R,Savary K,Morén A,Guibert S,Heldin CH,Ohlsson R,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Fri Jun 25 00:00:00 UTC 2010
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry
Bergström R,Savary K,Morén A,Guibert S,Heldin CH,Ohlsson R,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Fri Jun 25 00:00:00 UTC 2010
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry
Bergström R,Savary K,Morén A,Guibert S,Heldin CH,Ohlsson R,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Fri Jun 25 00:00:00 UTC 2010
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry
Bergström R,Savary K,Morén A,Guibert S,Heldin CH,Ohlsson R,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Fri Jun 25 00:00:00 UTC 2010
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry
Bergström R,Savary K,Morén A,Guibert S,Heldin CH,Ohlsson R,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Fri Jun 25 00:00:00 UTC 2010
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry
Bergström R,Savary K,Morén A,Guibert S,Heldin CH,Ohlsson R,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Fri Jun 25 00:00:00 UTC 2010
Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.
The Journal of biological chemistry
He W,Tan R,Dai C,Li Y,Wang D,Hao S,Kahn M,Liu Y
51-1500 was used in western blot to explore how transforming growth factor-beta1 regulates plasminogen activator inhibitor-1
Fri Aug 06 00:00:00 UTC 2010
Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.
The Journal of biological chemistry
He W,Tan R,Dai C,Li Y,Wang D,Hao S,Kahn M,Liu Y
51-1500 was used in western blot to explore how transforming growth factor-beta1 regulates plasminogen activator inhibitor-1
Fri Aug 06 00:00:00 UTC 2010
Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.
Developmental cell
Wilkes MC,Repellin CE,Hong M,Bracamonte M,Penheiter SG,Borg JP,Leof EB
51-1500 was used in western blot to investigate regulation of PAK2 activation in epithelial cultures
Sun Mar 01 00:00:00 UTC 2009
Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.
Developmental cell
Wilkes MC,Repellin CE,Hong M,Bracamonte M,Penheiter SG,Borg JP,Leof EB
51-1500 was used in western blot to investigate regulation of PAK2 activation in epithelial cultures
Sun Mar 01 00:00:00 UTC 2009
A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition.
Oncogene
Smith AP,Verrecchia A,Fagà G,Doni M,Perna D,Martinato F,Guccione E,Amati B
51-1500 was used in ChIP assay and western blot to elucidate the role of Myc in the TGFbeta response
Thu Jan 22 00:00:00 UTC 2009
Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Luo DD,Fielding C,Phillips A,Fraser D
51-1500 was used in western blot to discuss the role of transforming growth factor beta-1 in the pathogenesis of tubulointerstitial fibrosis and in repair following acute injury
Tue Sep 01 00:00:00 UTC 2009
SKI knockdown inhibits human melanoma tumor growth in vivo.
Pigment cell & melanoma research
Chen D,Lin Q,Box N,Roop D,Ishii S,Matsuzaki K,Fan T,Hornyak TJ,Reed JA,Stavnezer E,Timchenko NA,Medrano EE
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Tue Dec 01 00:00:00 UTC 2009
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
Gastroenterology
Dooley S,Hamzavi J,Ciuclan L,Godoy P,Ilkavets I,Ehnert S,Ueberham E,Gebhardt R,Kanzler S,Geier A,Breitkopf K,Weng H,Mertens PR
51-1500 was used in Western Blotting to show that hepatocytes undergo transforming growth factor (TGF)-beta-dependent epithelial-to-mesenchymal transition-like phenotypic changes and actively participate in fibrogenesis.
Fri Aug 01 00:00:00 UTC 2008
VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
The EMBO journal
Rudini N,Felici A,Giampietro C,Lampugnani M,Corada M,Swirsding K,Garrè M,Liebner S,Letarte M,ten Dijke P,Dejana E
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Wed Apr 09 00:00:00 UTC 2008
Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication.
American journal of physiology. Renal physiology
Tan R,He W,Lin X,Kiss LP,Liu Y
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Thu May 01 00:00:00 UTC 2008
Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes.
Hepatology (Baltimore, Md.)
Weng HL,Ciuclan L,Liu Y,Hamzavi J,Godoy P,Gaitantzi H,Kanzler S,Heuchel R,Ueberham U,Gebhardt R,Breitkopf K,Dooley S
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Mon Oct 01 00:00:00 UTC 2007
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Carcinogenesis
Pandey J,Umphress SM,Kang Y,Angdisen J,Naumova A,Mercer KL,Jacks T,Jakowlew SB
51-1500 was used in western blot to test if inactivation of TGF-beta1 combined with oncogenic activation of K-ras leads to early initiation and faster progression to lung adenocarcinoma
Sat Dec 01 00:00:00 UTC 2007
Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Banas MC,Parks WT,Hudkins KL,Banas B,Holdren M,Iyoda M,Wietecha TA,Kowalewska J,Liu G,Alpers CE
51-1500 was used in Immunohistochemistry to demonstrate expression of the TGF-beta-receptor-activated Smad2 and Smad3, the common mediator Smad4, and the inhibitory Smad7 in the developing human fetal kidney.
Thu Mar 01 00:00:00 UTC 2007
TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members.
Biochimica et biophysica acta
Wu Y,Zhang X,Salmon M,Lin X,Zehner ZE
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Thu Mar 01 00:00:00 UTC 2007
TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members.
Biochimica et biophysica acta
Wu Y,Zhang X,Salmon M,Lin X,Zehner ZE
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in ChIP assay
Thu Mar 01 00:00:00 UTC 2007
BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.
American journal of physiology. Lung cellular and molecular physiology
Izumi N,Mizuguchi S,Inagaki Y,Saika S,Kawada N,Nakajima Y,Inoue K,Suehiro S,Friedman SL,Ikeda K
Sun Jan 01 00:00:00 UTC 2006
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Wohlfert EA,Gorelik L,Mittler R,Flavell RA,Clark RB
51-1500 was used in western blot to report that Cbl-b plays an integral role in T cell TGF-beta signaling
Wed Feb 01 00:00:00 UTC 2006
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Molecular and cellular biology
Kurisaki A,Kurisaki K,Kowanetz M,Sugino H,Yoneda Y,Heldin CH,Moustakas A
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Immunofluorescence
Wed Feb 01 00:00:00 UTC 2006
Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures.
The Journal of biological chemistry
Wilkes MC,Leof EB
51-1500 was used in western blot to test if c-Abl is involved in the Smad-independent pathways of TGF-beta signaling
Fri Sep 22 00:00:00 UTC 2006
Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion.
The Journal of biological chemistry
Liu G,Ding W,Neiman J,Mulder KM
51-1500 was used in western blot to investigate how TGFbeta3 expression is regulated
Fri Oct 06 00:00:00 UTC 2006
TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Ménoret A,Myers LM,Lee SJ,Mittler RS,Rossi RJ,Vella AT
51-1500 was used in ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot to investigate TGFbeta activity due to mouse CD8 regulatory T cells.
Wed Nov 01 00:00:00 UTC 2006
Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells.
Cancer research
Burdette JE,Jeruss JS,Kurley SJ,Lee EJ,Woodruff TK
51-1500 was used in western blot to determine the role of activin A in the growth regulation of breast cancer cells
Thu Sep 01 00:00:00 UTC 2005
Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.
Oncogene
Romero-Gallo J,Sozmen EG,Chytil A,Russell WE,Whitehead R,Parks WT,Holdren MS,Her MF,Gautam S,Magnuson M,Moses HL,Grady WM
Thu Apr 21 00:00:00 UTC 2005
Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.
The Journal of biological chemistry
Quan T,He T,Voorhees JJ,Fisher GJ
Fri Mar 04 00:00:00 UTC 2005
Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.
The Journal of biological chemistry
Quan T,He T,Voorhees JJ,Fisher GJ
Fri Mar 04 00:00:00 UTC 2005
Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.
The Journal of biological chemistry
Quan T,He T,Voorhees JJ,Fisher GJ
Fri Mar 04 00:00:00 UTC 2005
Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
The Journal of biological chemistry
Boyer Arnold N,Korc M
Fri Jun 10 00:00:00 UTC 2005
Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
The Journal of biological chemistry
Boyer Arnold N,Korc M
Fri Jun 10 00:00:00 UTC 2005
Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
The Journal of biological chemistry
Boyer Arnold N,Korc M
Fri Jun 10 00:00:00 UTC 2005
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
The Journal of biological chemistry
Alliston T,Ko TC,Cao Y,Liang YY,Feng XH,Chang C,Derynck R
51-1500 was used in western blot to study activin-inducible transcription by Evi-1 and repression of bone mophogenetic protein
Fri Jun 24 00:00:00 UTC 2005
Loss of Smad3 in acute T-cell lymphoblastic leukemia.
The New England journal of medicine
Wolfraim LA,Fernandez TM,Mamura M,Fuller WL,Kumar R,Cole DE,Byfield S,Felici A,Flanders KC,Walz TM,Roberts AB,Aplan PD,Balis FM,Letterio JJ
51-1500 was used in western blot to examine the contribution of TGF-beta signaling in the pathogenesis of lymphoid neoplasia
Thu Aug 05 00:00:00 UTC 2004
Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.
The Journal of clinical investigation
Daniels CE,Wilkes MC,Edens M,Kottom TJ,Murphy SJ,Limper AH,Leof EB
51-1500 was used in western blot to study the role of TGF-beta-induced fibrosis mediated by activation of the Abelson tyrosine kinase
Mon Nov 01 00:00:00 UTC 2004
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition.
The EMBO journal
Zavadil J,Cermak L,Soto-Nieves N,Böttinger EP
51-1500 was used in western blot to demonstrate functional roles for Smad3, Hey1, and Jagged1/Notch in mediating TGF-beta-induced epithelial-to-mesenchymal transitions
Wed Mar 10 00:00:00 UTC 2004
Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,Byfield SD,Parks WT,Stuelten CH,Nemani D,Zhang YE,Roberts AB
Thu Jul 01 00:00:00 UTC 2004
Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,Byfield SD,Parks WT,Stuelten CH,Nemani D,Zhang YE,Roberts AB
Thu Jul 01 00:00:00 UTC 2004
Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis.
Oncogene
Park SS,Eom YW,Kim EH,Lee JH,Min DS,Kim S,Kim SJ,Choi KS
51-1500 was used in western blot to investigate the involvement of c-Src in the regulation of TGF-beta1-induced apoptosis
Thu Aug 19 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.
Molecular and cellular biology
Frederick JP,Liberati NT,Waddell DS,Shi Y,Wang XF
51-1500 was used in western blot to discuss mechanisms that regulate TGF-beta-mediated transcriptional repression
Mon Mar 01 00:00:00 UTC 2004
Signaling "cross-talk" between TGF-beta1 and ECM signals in chondrocytic cells.
Cellular signalling
Schneiderbauer MM,Dutton CM,Scully SP
51-1500 was used in western blot to elucidate how the integrin pathway regulates downstream effectors of the TGF-beta1 pathway in chondrocytic cell signaling
Fri Oct 01 00:00:00 UTC 2004
Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells.
Molecular biology of the cell
Murphy SJ,Doré JJ,Edens M,Coffey RJ,Barnard JA,Mitchell H,Wilkes M,Leof EB
51-1500 was used in western blot to determine the spatial distribution of transforming growth factor-beta receptors
Tue Jun 01 00:00:00 UTC 2004
Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta.
The Journal of biological chemistry
Major MB,Jones DA
Published figure using SMAD3 polyclonal antibody (Product # 51-1500) in Western Blot
Fri Feb 13 00:00:00 UTC 2004
Cellular response to hypoxia involves signaling via Smad proteins.
Blood
Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA
Sat Mar 15 00:00:00 UTC 2003
Cellular response to hypoxia involves signaling via Smad proteins.
Blood
Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA
Sat Mar 15 00:00:00 UTC 2003
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,DaCosta Byfield S,Parks WT,Yoo S,Felici A,Tang B,Piek E,Wakefield LM,Roberts AB
Mon Dec 01 00:00:00 UTC 2003
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,DaCosta Byfield S,Parks WT,Yoo S,Felici A,Tang B,Piek E,Wakefield LM,Roberts AB
Mon Dec 01 00:00:00 UTC 2003
Intracellular dynamics of Smad-mediated TGFbeta signaling.
Journal of cellular physiology
Greene RM,Nugent P,Mukhopadhyay P,Warner DR,Pisano MM
51-1500 was used in western blot to identify specific genes that function as downstream mediators of TGFbeta during palatal ontogenesis.
Sat Nov 01 00:00:00 UTC 2003
Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3.
Molecular and cellular biology
Wilkes MC,Murphy SJ,Garamszegi N,Leof EB
51-1500 was used in western blot to demonstrate that PAK2 is a novel Smad-independent pathway that differentiates TGF-beta signaling in fibroblasts and epithelial cells.
Mon Dec 01 00:00:00 UTC 2003
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
Molecular and cellular biology
Law BK,Chytil A,Dumont N,Hamilton EG,Waltner-Law ME,Aakre ME,Covington C,Moses HL
51-1500 was used in western blot to study the mechanism by which rapamycin potentiates TGFbeta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
Sun Dec 01 00:00:00 UTC 2002
Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.
Mechanisms of development
Oxburgh L,Robertson EJ
51-1500 was used in immunohistochemistry - paraffin section to characterize expression of Smad proteins in the developing kidney.
Fri Mar 01 00:00:00 UTC 2002
Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway.
The Journal of biological chemistry
Yue J,Mulder KM
51-1500 was used in gel shift to assess the role of the Ras/MAPK pathways and Smads in TGFbeta3 induction of TGFbeta1 expression in untransformed lung and intestinal epithelial cells.
Fri Oct 06 00:00:00 UTC 2000
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.jpg?time=20250104?time=20250104 "SMAD3 Antibody (51-1500) in WB")
.jpg?time=20250104?time=20250104 "SMAD3 Antibody (51-1500) in WB")
.jpg?time=20250104?time=20250104 "SMAD3 Antibody (51-1500) in ChIP, GS")
