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Proteintech
SMARCA4/BRG1 Polyclonal Antibody
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Product Details
21634-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Bovine,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SMARCA4/BRG1 Fusion Protein Ag16256 (207-298 aa encoded by BC150298)
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KRPMPGMQQ QMPTLPPPSV SATGPGPGPG PGPGPGPGPA PPNYSRPHGM GGPNMPPPGP SGVPPGMPGQ PPGGPPKPWP EGPMANAAAP TST (207-298 aa encoded by BC150298)
Target Information
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1
Gene Aliases: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; brg-1; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; RTPS2; SMARCA4; SNF2; SNF2B; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2
UniProt ID: (Human) P51532, (Mouse) Q3TKT4
Entrez Gene ID: (Human) 6597, (Mouse) 20586, (Rat) 171379
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
RNA polymerase I CORE element sequence-specific DNA binding
p53 binding
transcription coactivator activity
transcription corepressor activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
transcription factor binding
Tat protein binding
nucleosomal DNA binding
protein N-terminus binding
androgen receptor binding
DNA polymerase binding
lysine-acetylated histone binding
nucleotide binding
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
protein complex binding
histone binding
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
blood vessel development
vasculogenesis
in utero embryonic development
blastocyst growth
blastocyst hatching
liver development
outflow tract morphogenesis
nucleosome assembly
nucleosome disassembly
chromatin remodeling
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
glial cell fate determination
heart development
positive regulation of cell proliferation
DNA methylation on cytosine within a CG sequence
chromatin modification
stem cell population maintenance
neurogenesis
positive regulation of Wnt signaling pathway
extracellular matrix organization
keratinocyte differentiation
negative regulation of cell growth
regulation of cell migration
forebrain development
hindbrain development
embryonic hindlimb morphogenesis
aortic smooth muscle cell differentiation
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation by host of viral transcription
histone H3 acetylation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ morphogenesis
epidermis morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
definitive erythrocyte differentiation
heart trabecula formation
negative regulation of androgen receptor signaling pathway
pharyngeal arch artery morphogenesis
lens fiber cell development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
neural retina development
regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter during mitosis
spermatid development
covalent chromatin modification
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of glucose mediated signaling pathway
beta-catenin-TCF complex assembly
negative regulation of G1/S transition of mitotic cell cycle
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