Proteintech

SMARCC1 Polyclonal Antibody

SMARCC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SMARCC1 Antibody (17722-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 17722-1-AP (SMARCC1 antibody) at dilution of 1:100 (under 40x lens).

SMARCC1 Antibody in Immunoprecipitation (IP)

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Product Details

17722-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:16,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SMARCC1 Fusion Protein Ag12109 (756-1105 aa encoded by BC050564)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GLESSCIAG TGPDEPEKLE GAEEEKMEAD PDGQQPEKAE NKVENETDEG DKAQDGENEK NSEKEQDSEV SEDTKSEEKE TEENKELTDT CKERESDTGK KKVEHEISEG NVATAAAAAL ASAATKAKHL AAVEERKIKS LVALLVETQM KKLEIKLRHF EELETIMDRE KEALEQQRQQ LLTERQNFHM EQLKYAELRA RQQMEQQQHG QNPQQAHQHS GGPGLAPLGA AGHPGMMPHQ QPPPYPLMHH QMPPPHPPQP GQIPGPGSMM PGQHMPGRMI PTVAANIHPS GSGPTPPGMP PMPGNILGPR VPLTAPNGMY PPPPQQQPPP PPPADGVPPP PAPGPPASAA P (756-1105 aa encoded by BC050564)

Target Information

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction.

Cancer discovery

Li J,Mulvihill TS,Li L,Barrott JJ,Nelson ML,Wagner L,Lock IC,Pozner A,Lambert SL,Ozenberger BB,Ward MB,Grossmann AH,Liu T,Banito A,Cairns BR,Jones KB

Fri Oct 01 00:00:00 UTC 2021

A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction.

Cancer discovery

Li J,Mulvihill TS,Li L,Barrott JJ,Nelson ML,Wagner L,Lock IC,Pozner A,Lambert SL,Ozenberger BB,Ward MB,Grossmann AH,Liu T,Banito A,Cairns BR,Jones KB

Fri Oct 01 00:00:00 UTC 2021

HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.

Nucleic acids research

Zhu X,Lan B,Yi X,He C,Dang L,Zhou X,Lu Y,Sun Y,Liu Z,Bai X,Zhang K,Li B,Li MJ,Chen Y,Zhang L

Thu Jul 09 00:00:00 UTC 2020

Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex.

Molecular and cellular biology

McClellan D,Casey MJ,Bareyan D,Lucente H,Ours C,Velinder M,Singer J,Lone MD,Sun W,Coria Y,Mason CC,Engel ME

Mon Jul 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: BAF155; BRG1-associated factor 155; chromatin remodeling complex BAF155 subunit; mammalian chromatin remodeling complex BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF complex subunit SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3-related protein

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Gene Aliases: AI115498; BAF155; CRACC1; Rsc8; SMARCC1; SRG3; SWI3

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UniProt ID: (Human) Q92922, (Mouse) P97496

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Entrez Gene ID: (Human) 6599, (Rat) 301020, (Mouse) 20588

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcription coactivator activity protein binding nucleosomal DNA binding protein N-terminus binding molecular_function chromatin binding DNA binding

Process(es)

nucleosome disassembly chromatin remodeling insulin receptor signaling pathway organ morphogenesis prostate gland development negative regulation of proteasomal ubiquitin-dependent protein catabolic process ATP-dependent chromatin remodeling positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter DNA packaging transcription, DNA-templated regulation of transcription, DNA-templated nervous system development chromatin modification regulation of transcription from RNA polymerase II promoter covalent chromatin modification

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SMARCC1 Polyclonal Antibody

SMARCC1 Antibody (17722-1-AP) in IHC (P)

Product Details

17722-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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