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SMC3 Antibody (61131) in WB
SMC3 antibody (pAb) tested by Western blot. Detection of SMC3 by Western blot analysis. Lane 1: Nuclear extract of HeLa cells (20 µg). Lane 2: Nuclear extract of Hep G2 cells (20 µg). Lane 3: Nuclear extract of HEK293 cells (20 µg). Lane 4: Nuclear extract of U2OS cells (20 µg). All were probed with SMC3 antibody (pAb) at a 1:500 dilution.
Product Details
61131
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This SMC3 antibody was raised against a peptide in the C-terminal region of human SMC3.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2688005
Target Information
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bamacan; Basement membrane-associated chondroitin proteoglycan; Chondroitin sulfate proteoglycan 6; chondroitin sulfate proteoglycan 6 (bamacan); Chromosome-associated polypeptide; hCAP; SMC protein 3; Structural maintenance of chromosomes protein 3
Gene Aliases: BAM; BMH; CDLS3; CSPG6; HCAP; SMC3; SMC3L1
UniProt ID: (Human) Q9UQE7
Entrez Gene ID: (Human) 9126
regulation of DNA replication
DNA repair
mitotic spindle organization
sister chromatid cohesion
mitotic sister chromatid cohesion
mitotic nuclear division
meiotic nuclear division
signal transduction
protein sumoylation
stem cell population maintenance
negative regulation of DNA endoreduplication
cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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