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Proteintech
SMG6 Monoclonal Antibody (1D2G2)
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Product Details
68109-1-IG150UL
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1D2G2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EST1 telomerase component homolog A; EST1-like protein A; Ever shorter telomeres 1A; hEST1A; hSmg5/7a; Nonsense mediated mRNA decay factor SMG6; Smg-6 homolog; smg-6 homolog, nonsense mediated mRNA decay factor; SMG6 nonsense mediated mRNA decay factor; telomerase subunit EST1A; Telomerase-binding protein EST1A
Gene Aliases: AI317223; AU041178; C17orf31; EST1A; hSMG5/7a; KIAA0732; SMG-6; SMG6
UniProt ID: (Human) Q86US8, (Mouse) P61406
Entrez Gene ID: (Human) 23293, (Mouse) 103677
endoribonuclease activity
protein binding
telomeric DNA binding
ribonucleoprotein complex binding
metal ion binding
telomerase RNA binding
DNA polymerase binding
DNA binding
nuclease activity
endonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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