Proteintech

SMO Monoclonal Antibody (2B10A11), CoraLite® Plus 488

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CL488-66851

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Dog, Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2B10A11

Immunogen

Recombinant Protein

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: frizzled family member 11; HGNC:11119; Protein Gx; Protein SMOH; Protein smoothened; seven transmembrane helix receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor

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Gene Aliases: FZD11; Gx; SMO; SMOH

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UniProt ID: (Human) Q99835

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Entrez Gene ID: (Human) 6608, (Dog) 482262

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Function(s)
G-protein coupled receptor activity patched binding protein binding drug binding Wnt-protein binding Wnt-activated receptor activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis osteoblast differentiation in utero embryonic development cell fate specification neural crest cell migration heart looping positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation determination of left/right asymmetry in lateral mesoderm type B pancreatic cell development G-protein coupled receptor signaling pathway smoothened signaling pathway positive regulation of hh target transcription factor activity ventral midline determination midgut development anterior/posterior pattern specification positive regulation of gene expression negative regulation of gene expression dentate gyrus development cerebellar cortex morphogenesis thalamus development dorsal/ventral neural tube patterning smoothened signaling pathway involved in ventral spinal cord patterning smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation central nervous system neuron differentiation cerebral cortex development negative regulation of epithelial cell differentiation hair follicle morphogenesis protein localization to nucleus multicellular organism growth non-canonical Wnt signaling pathway positive regulation of multicellular organism growth positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth negative regulation of apoptotic process negative regulation of DNA binding positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth astrocyte activation skeletal muscle fiber development forebrain morphogenesis homeostasis of number of cells within a tissue positive regulation of epithelial cell proliferation protein stabilization myoblast migration negative regulation of hair follicle development canonical Wnt signaling pathway detection of cell density by contact stimulus involved in contact inhibition atrial septum morphogenesis mammary gland epithelial cell differentiation epithelial-mesenchymal cell signaling somite development pancreas morphogenesis left/right axis specification cellular response to cholesterol renal system development mesenchymal to epithelial transition involved in metanephric renal vesicle formation positive regulation of branching involved in ureteric bud morphogenesis regulation of stem cell population maintenance regulation of heart morphogenesis
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