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Product Details
PA5-144186
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Sphingomyelin phosphodiesterase 3 protein (401-655AA)
Conjugate
Form
Liquid
Concentration
4 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093624
Target Information
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; Sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Gene Aliases: 4631433G07Rik; AI427456; AW537966; fro; NSMASE2; SMPD3
UniProt ID: (Human) Q9NY59, (Mouse) Q9JJY3
Entrez Gene ID: (Human) 55512, (Mouse) 58994
hematopoietic progenitor cell differentiation
sphingomyelin catabolic process
glycosphingolipid metabolic process
cell cycle
peptide hormone secretion
positive regulation of exosomal secretion
positive regulation of ceramide biosynthetic process
lipid metabolic process
sphingolipid metabolic process
sphingomyelin metabolic process
signal transduction
multicellular organism development
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