Invitrogen

SMYD1 Polyclonal Antibody

SMYD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SMYD1 Antibody (PA5-84544) in IHC (P)

Immunohistochemical analysis of SMYD1 in human prostate using SMYD1 Polyclonal Antibody (Product # PA5-84544) shows low expression as expected.

SMYD1 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

SMYD1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of SMYD1 demonstrates antibody specificity. Immunohistochemical analysis of SMYD1 using anti-SMYD1 Polyclonal Antibody (Product #PA5-84544), shows significant staining of SMYD1 in skeletal muscle and shows minimal or weak staining in prostate tissues. The relative expression levels of SMYD1 within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-84544

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SMYD1. Recombinant protein control fragment (Product #RP-103443).

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2791695

Product Specific Information

Immunogen sequence: NIRLAARIMW RVEREGTGLT EGCLVSVDDL QNHVEHFGEE EQKDLRVDVD TFLQYWPPQS QQFSMQYISH IF

Target Information

Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth.

Acta neuropathologica communications

Cleveland AH,Malawsky D,Churiwal M,Rodriguez C,Reed F,Schniederjan M,Velazquez Vega JE,Davis I,Gershon TR

PA5-84544 was used in Immunohistochemistry (Paraffin) to define a role for the PRC2 in preventing inappropriate, non-neural fates during postnatal neurogenesis, and caution that targeting the PRC2 in SHH medulloblastoma may not produce durable therapeutic effects.

Thu Jan 12 00:00:00 UTC 2023

PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth.

Acta neuropathologica communications

Cleveland AH,Malawsky D,Churiwal M,Rodriguez C,Reed F,Schniederjan M,Velazquez Vega JE,Davis I,Gershon TR

Thu Jan 12 00:00:00 UTC 2023

Bioinformatics

Protein Aliases: CD8 beta opposite; Histone-lysine N-methyltransferase SMYD1; SET and MYND domain-containing protein 1; zinc finger, MYND domain containing 18

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Gene Aliases: BOP; KMT3D; SMYD1; ZMYND18; ZMYND22

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UniProt ID: (Human) Q8NB12

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Entrez Gene ID: (Human) 150572

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Function(s)

DNA binding transcription corepressor activity protein binding histone-lysine N-methyltransferase activity metal ion binding

Process(es)

chromatin remodeling transcription, DNA-templated heart development positive regulation of myotube differentiation histone lysine methylation skeletal muscle cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SMYD1 Polyclonal Antibody

SMYD1 Antibody (PA5-84544) in IHC (P)

Product Details

PA5-84544

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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