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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SNAIL Antibodies

          Proteintech

          SNAI1 Polyclonal Antibody

          384 References
          View all (36) SNAIL antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
          Questions & Answers

          Cite SNAI1 Polyclonal Antibody

          • Antibody Testing Data (6)
          SNAI1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          SNAI1 Antibody in Western Blot (WB)
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          FIGURE: 1 / 6

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          SNAI1 Antibody (13099-1-AP) in WB

          Various lysates were subjected to SDS PAGE followed by western blot with (Product # 13099-1-AP) SNAI1 antibody at dilution of 1:1,500 incubated at room temperature for 1.5 hours. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SNAI1 Antibody in Western Blot (WB)
          SNAI1 Antibody in Western Blot (WB)
          SNAI1 Antibody in Western Blot (WB)
          SNAI1 Antibody in Western Blot (WB)
          SNAI1 Antibody in Western Blot (WB)
          SNAI1 Antibody in Immunoprecipitation (IP)

          Product Details

          13099-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          View 310 publications 310 publications

          Immunohistochemistry (IHC)

          Assay-dependent
          View 33 publications 33 publications

          Immunocytochemistry (ICC/IF)

          -
          View 27 publications 27 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 3 publications 3 publications

          ChIP assay (ChIP)

          Assay-dependent
          View 2 publications 2 publications

          Miscellaneous PubMed (MISC)

          -
          View 3 publications 3 publications

          Not applicable (N/A)

          -
          View 6 publications 6 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          SNAI1 Fusion Protein Ag3723 (1-264 aa encoded by BC012910)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.3 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: MPRSFLVRK PSDPNRKPNY SELQDSNPEF TFQQPYDQAH LLAAIPPPEI LNPTASLPML IWDSVLAPQA QPIAWASLRL QESPRVAELT SLSDEDSGKG SQPPSPPSPA PSSFSSTSVS SLEAEAYAAF PGLGQVPKQL AQLSEAKDLQ ARKAFNCKYC NKEYLSLGAL KMHIRSHTLP CVCGTCGKAF SRPWLLQGHV RTHTGEKPFS CPHCSRAFAD RSNLRAHLQT HSDVKKYQCQ ACARTFSRMS LLHKHQESGC SGCPR (1-264 aa encoded by BC012910)

          Target Information

          Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Protein sna; Protein snail homolog 1; Sna protein; snai; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail homolog 1; Zinc finger protein SNAI1

          View more View less

          Gene Aliases: AI194338; dJ710H13.1; SLUGH2; SNA; Sna1; SNAH; SNAI1; SNAIL; SNAIL1

          View more View less

          UniProt ID: (Human) O95863, (Mouse) Q02085

          View more View less

          Entrez Gene ID: (Human) 6615, (Mouse) 20613, (Rat) 116490

          View more View less

          Function(s)
          RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding kinase binding metal ion binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation mesoderm formation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition negative regulation of vitamin D biosynthetic process cell migration positive regulation of cell migration hair follicle morphogenesis negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription, DNA-templated palate development cartilage morphogenesis trophoblast giant cell differentiation negative regulation of cell differentiation involved in embryonic placenta development left/right pattern formation Notch signaling involved in heart development negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of bicellular tight junction assembly regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development mesoderm development negative regulation of transcription, DNA-templated negative regulation of cell cycle
          It has to be done as per old AB suggested Products section.
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