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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SLUG Antibodies

          Proteintech

          SNAI2 Polyclonal Antibody

          130 References
          View all (53) SLUG antibodies

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          Datasheet
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          Datasheet
          Protocols
          Questions & Answers

          Cite SNAI2 Polyclonal Antibody

          • Antibody Testing Data (4)
          SNAI2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          SNAI2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          SNAI2 Antibody (12129-1-AP) in ICC/IF

          Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using SNAI2 antibody (Product # 12129-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SNAI2 Antibody in Immunocytochemistry (ICC/IF)
          SNAI2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNAI2 Antibody in Western Blot (WB)
          SNAI2 Antibody in Flow Cytometry (Flow)

          Product Details

          12129-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,500
          View 109 publications 109 publications

          Immunohistochemistry (IHC)

          -
          View 14 publications 14 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:400
          -

          Immunocytochemistry (ICC/IF)

          1:400
          View 5 publications 5 publications

          Flow Cytometry (Flow)

          0.2 µg
          -

          Not applicable (N/A)

          -
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human, Mouse

          Published species

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          SNAI2 Fusion Protein Ag2773

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          333 µg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice

          Product Specific Information

          Aliquoting is unnecessary for -20°C storage.

          Target Information

          Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; slug, chicken homolog; snail family zinc finger 2; snail homolog 2; Zinc finger protein SNAI2

          View more View less

          Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D

          View more View less

          UniProt ID: (Human) O43623, (Mouse) P97469

          View more View less

          Entrez Gene ID: (Human) 6591, (Mouse) 20583

          View more View less

          Function(s)
          transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding sequence-specific DNA binding metal ion binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation cell migration involved in endocardial cushion formation transcription, DNA-templated negative regulation of cell adhesion involved in substrate-bound cell migration Notch signaling pathway sensory perception of sound negative regulation of keratinocyte proliferation negative regulation of vitamin D biosynthetic process neural crest cell development positive regulation of cell migration negative regulation of chondrocyte differentiation regulation of chemokine production negative regulation of cell adhesion mediated by integrin positive regulation of histone acetylation negative regulation of catenin import into nucleus desmosome disassembly pigmentation negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of osteoblast differentiation white fat cell differentiation palate development canonical Wnt signaling pathway epithelium development cartilage morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of stem cell proliferation regulation of bicellular tight junction assembly negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development response to radiation cell migration cellular response to platelet-derived growth factor stimulus regulation of apoptotic process negative regulation of apoptotic process wound healing, spreading of cells positive regulation of endothelial cell chemotaxis
          It has to be done as per old AB suggested Products section.
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