Proteintech

SNAP25 Monoclonal Antibody (3E4B7)

SNAP25 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

SNAP25 Antibody (60159-1-IG) in ICC/IF

Immunofluorescent analysis of PC-12 cells using 60159-1-IG (SNAP25 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

SNAP25 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SNAP25 Antibody in Immunoprecipitation (IP)

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Product Details

60159-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:20,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

3E4B7

Immunogen

SNAP25 Fusion Protein Ag6695 (1-206 aa encoded by BC010647)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.61 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEDADMRN ELEEMQRRAD QLADESLEST RRMLQLVEES KDAGIRTLVM LDEQGEQLDR VEEGMNHINQ DMKEAEKNLK DLGKCCGLFI CPCNKLKSSD AYKKAWGNNQ DGVVASQPAR VVDEREQMAI SGGFIRRVTN DARENEMDEN LEQVSGIIGN LRHMALDMGN EIDTQNRQID RIMEKADSNK TRIDEANQRA TKMLGSG (1-206 aa encoded by BC010647)

Target Information

SNAP25 is a t-SNARE involved in the molecular regulation of neurotransmitter release. It may play a role in the synaptic function of specific neuronal systems. SNAP25 associates with proteins involved in vesicle docking and membrane fusion. It also regulates plasma membrane recycling through its interaction with CENPF. Mutations in the gene can results in myasthenic syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum.

Biochimica et biophysica acta. Molecular basis of disease

Zhang J,Li J,You P,Jiang H,Liu Y,Han D,Liu M,Yu H,Su B

Sat Apr 01 00:00:00 UTC 2023

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading.

The Journal of clinical investigation

Wang C,Nambiar A,Strickland MR,Lee C,Parhizkar S,Moore AC,Musiek ES,Ulrich JD,Holtzman DM

Mon Jul 17 00:00:00 UTC 2023

Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Wang ZJ,Rein B,Zhong P,Williams J,Cao Q,Yang F,Zhang F,Ma K,Yan Z

Sun Aug 01 00:00:00 UTC 2021

Transcriptomic analysis of human brains with Alzheimer's disease reveals the altered expression of synaptic genes linked to cognitive deficits.

Brain communications

Williams JB,Cao Q,Yan Z

Mon May 06 00:00:00 UTC 2024

Transcriptomic analysis of human brains with Alzheimer's disease reveals the altered expression of synaptic genes linked to cognitive deficits.

Brain communications

Williams JB,Cao Q,Yan Z

Mon May 06 00:00:00 UTC 2024

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 UTC 2020

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 UTC 2020

A Novel Botulinum Toxin TAT-EGFP-HCS Fusion Protein Capable of Specific Delivery Through the Blood-brain Barrier to the Central Nervous System.

CNS & neurological disorders drug targets

Hao F,Feng Y,Guan Y

Mon Mar 16 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: ALMS1; blind drunk; CG17676; CG17884; CG40452; Dmel CG40452; Dmel_CG40452; FLJ23079; HGNC:11132; resistance to inhibitors of cholinesterase 4 homolog; SNAP 25; SNAP-25; snp25; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25 kDa; synaptosomal-associated protein, 25kDa; synaptosome associated protein 25kDa

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Gene Aliases: bA416N4.2; Bdr; CMS18; dJ1068F16.2; GENA70; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP-25a; SNAP-25B; SNAP25; sp; SUP

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UniProt ID: (Human) P60880, (Rat) P60881, (Mouse) P60879

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Entrez Gene ID: (Human) 6616, (Rat) 25012, (Mouse) 20614

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Function(s)

SNAP receptor activity protein binding syntaxin-1 binding calcium-dependent protein binding SNARE binding voltage-gated potassium channel activity myosin binding protein domain specific binding protein N-terminus binding ion channel binding

Process(es)

exocytosis neurotransmitter secretion axonogenesis long-term memory regulation of neuron projection development synaptic vesicle priming endosomal transport growth hormone secretion sleep synaptic vesicle fusion to presynaptic active zone membrane positive regulation of insulin secretion positive regulation of hormone secretion calcium ion-regulated exocytosis of neurotransmitter regulation of synapse assembly long-term synaptic potentiation regulation of establishment of protein localization potassium ion transmembrane transport neurotransmitter uptake chemical synaptic transmission locomotory behavior associative learning glutamate secretion synaptic vesicle exocytosis synaptic vesicle docking regulation of insulin secretion regulation of ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNAP25 Monoclonal Antibody (3E4B7)

SNAP25 Antibody (60159-1-IG) in ICC/IF

Product Details

60159-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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