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Product Details
17818-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SNCAIP Fusion Protein Ag12147 (253-603 aa encoded by BC094759)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ILRQLLGKE ISENVCTQEK LSLEFQDAQA SSRNSKKIPL EKRELKLARL RQLMQRSLSE SDTDSNNSED PKTTPVRKAD RPRPQPIVES VESMGSAESL HLMIKKHTLA SGGRRFPFSI KASKSLDGHS PSPTSESSEP DLESQYPGSG SIPPNQPSGD PQQPSPDSTA AQKVATSPKS ALKSPSSKRR TSQNLKLRVT FEEPVVQMEQ PSLELNGEKD KDKGRTLQRT STSNESGDQL KRPFGAFRSI METLSGNQNN NNNYQAANQL KTSTLPLTSL GRKTDAKGNP ASSASKGKNK AEMYSSCINL SSNMLIEEHL CNDTRHNDIN RKMKKSYSIK HIAEPESKEL FL (253-603 aa encoded by BC094759)
Target Information
Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-synuclein-interacting protein; MGC39814; Sph1; Synphilin 1; Synphilin-1; synuclein, alpha interacting protein
Gene Aliases: 2810407O15Rik; 4933427B05Rik; BB104594; SNCAIP; Sph1; SYPH1
UniProt ID: (Human) Q9Y6H5, (Mouse) Q99ME3
Entrez Gene ID: (Human) 9627, (Mouse) 67847
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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