Proteintech

SND1 Monoclonal Antibody (1A6A4)

SND1 Antibody in Immunocytochemistry (ICC/IF)

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SND1 Antibody (60265-1-IG) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 60265-1-IG (SND1 antibody) at dilution of 1:50 and and Rhodamine-labeled goat anti-mouse IGG (red).

SND1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SND1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

60265-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

ELISA (ELISA)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A6A4

Immunogen

SND1 Fusion Protein Ag1200 (548-911 aa encoded by BC017180)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TCLITFLLA GIECPRGARN LPGLVQEGEP FSEEATLFTK ELVLQREVEV EVESMDKAGN FIGWLHIDGA NLSVLLVEHA LSKVHFTAER SSYYKSLLSA EEAAKQKKEK VWAHYEEQPV EEVMPVLEEK ERSASYKPVF VTEITDDLHF YVQDVETGTQ LEKLMENMRN DIASHPPVEG SYAPRRGEFC IAKFVDGEWY RARVEKVESP AKIHVFYIDY GNREVLPSTR LGTLSPAFST RVLPAQATEY AFAFIQVPQD DDARTDAVDS VVRDIQNTQC LLNVEHLSAG CPHVTLQFAD SKGDVGLGLV KEGLVMVEVR KEKQFQKVIT EYLNAQESAK SARLNLWRYG DFRADDADEF GYSR (548-911 aa encoded by B C017180)

Target Information

SND1/P100 (staphylococcal nuclease and tudor domain containing 1), also known as TudorSN, functions in the Pim-1 regulation of Myb activity and acts as a transcriptional activator of EBNA-2. It also interacts with EAV, NSP1, GTF2E1 and GTF2E2, and forms a ternary complex with Stat6 and POLR2A. The staphylococcal nuclease-like (SN)-domains directly interact with amino acids 1099-1758 of CBP. SND1/P100 plays an important role in the assembly of Stat6 transcriptome and stimulates IL-4-dependent transcription by mediating interaction between Stat6 and CBP.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.

Journal of neuroinflammation

Huang C,Sun L,Xiao C,You W,Sun L,Wang S,Zhang Z,Liu S

Fri Feb 17 00:00:00 UTC 2023

Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.

Journal of neuroinflammation

Huang C,Sun L,Xiao C,You W,Sun L,Wang S,Zhang Z,Liu S

Fri Feb 17 00:00:00 UTC 2023

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.

Journal of experimental & clinical cancer research : CR

Chen L,Song Y,Hou T,Li X,Cheng L,Li Y,Xing Y

Fri Jun 03 00:00:00 UTC 2022

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.

Journal of experimental & clinical cancer research : CR

Chen L,Song Y,Hou T,Li X,Cheng L,Li Y,Xing Y

Fri Jun 03 00:00:00 UTC 2022

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.

Journal of experimental & clinical cancer research : CR

Chen L,Song Y,Hou T,Li X,Cheng L,Li Y,Xing Y

Fri Jun 03 00:00:00 UTC 2022

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8⁺ T cell response in tumor.

Science advances

Wang Y,Wang X,Cui X,Zhuo Y,Li H,Ha C,Xin L,Ren Y,Zhang W,Sun X,Ge L,Liu X,He J,Zhang T,Zhang K,Yao Z,Yang X,Yang J

Fri May 01 00:00:00 UTC 2020

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8⁺ T cell response in tumor.

Science advances

Wang Y,Wang X,Cui X,Zhuo Y,Li H,Ha C,Xin L,Ren Y,Zhang W,Sun X,Ge L,Liu X,He J,Zhang T,Zhang K,Yao Z,Yang X,Yang J

Fri May 01 00:00:00 UTC 2020

The phosphorylation of Tudor-SN mediated by JNK is involved in the regulation of milk protein synthesis induced by prolactin in BMECs.

Journal of cellular physiology

Zhang S,Qi H,Wen XP,Li P,Gao XJ,Ao JX

Wed May 01 00:00:00 UTC 2019

The Tudor SND1 protein is an m⁶A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.

eLife

Baquero-Perez B,Antanaviciute A,Yonchev ID,Carr IM,Wilson SA,Whitehouse A

Thu Oct 24 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivator p100; p100 co-activator; p100 EBNA2 co-activator; p105 coactivator; SND p102; SND1-BRAF fusion; staphylococcal nuclease domain containing 1; Staphylococcal nuclease domain-containing protein 1; testis tissue sperm-binding protein Li 82P; Tudor domain-containing protein 11; Tudor-SN; TudorSN

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Gene Aliases: AL033314; p100; SND p102; SND1; TDRD11; Tudor-SN

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UniProt ID: (Human) Q7KZF4, (Rat) Q66X93, (Mouse) Q78PY7

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Entrez Gene ID: (Human) 27044, (Rat) 64635, (Mouse) 56463

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Function(s)

transcription cofactor activity nuclease activity protein binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion nucleic acid binding transcription coactivator activity

Process(es)

osteoblast differentiation transcription, DNA-templated regulation of transcription, DNA-templated gene silencing by RNA nucleic acid phosphodiester bond hydrolysis viral process cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SND1 Monoclonal Antibody (1A6A4)

SND1 Antibody (60265-1-IG) in ICC/IF

Product Details

60265-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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