Invitrogen

SNW1 Polyclonal Antibody

SNW1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

SNW1 Antibody (PA5-29070) in ICC/IF

Immunocytochemistry analysis of SNW1 in paraformaldehyde-fixed HeLa. Samples were incubated with SNW1 polyclonal antibody (Product # PA5-29070) using a dilution of 1:500.

SNW1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

PA5-29070

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:10,000

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Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000

Immunocytochemistry (ICC/IF)

1:100-1:1,000

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human NCOA62. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.85 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2546546

Product Specific Information

Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse liver.

Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (80%), Xenopus laevis (83%), Chimpanzee (99%), Bovine (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes.

PLoS pathogens

Xu H,Perez RD,Frey TR,Burton EM,Mannemuddhu S,Haley JD,McIntosh MT,Bhaduri-McIntosh S

PA5-29070 was used in Western Blot to examine cellular replication forks in EBV-transformed B cells using iPOND (isolation of Proteins on Nascent DNA)-mass spectrometry and identify several cellular proteins that have not previously been linked to DNA replication.

Sun Dec 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: homolog of Drosophila BX42; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; PPS; SKI interacting protein; SKI-interacting protein; SNW domain-containing protein 1

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Gene Aliases: 2310008B08Rik; AW048543; Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SNW1

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UniProt ID: (Human) Q13573, (Mouse) Q9CSN1

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Entrez Gene ID: (Human) 22938, (Mouse) 66354

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Function(s)

transcription coactivator activity transcription corepressor activity Notch binding protein binding nuclear hormone receptor binding vitamin D receptor binding retinoic acid receptor binding poly(A) RNA binding SMAD binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter mRNA splicing, via spliceosome transcription, DNA-templated regulation of transcription, DNA-templated mRNA processing RNA splicing positive regulation of transforming growth factor beta receptor signaling pathway skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of mRNA splicing, via spliceosome retinoic acid receptor signaling pathway regulation of retinoic acid receptor signaling pathway positive regulation of neurogenesis positive regulation of histone H3-K4 methylation regulation of vitamin D receptor signaling pathway positive regulation of vitamin D receptor signaling pathway cellular response to retinoic acid regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter Notch signaling pathway viral process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNW1 Polyclonal Antibody

SNW1 Antibody (PA5-29070) in ICC/IF

Product Details

PA5-29070

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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