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Invitrogen
SNX1 Polyclonal Antibody
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FIGURE: 1 / 6
SNX1 Antibody (PA1-836) in ICC/IF
Immunofluorescent analysis of SNX1 (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a SNX1 polyclonal antibody (Product # PA1-836) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugat... View More
Product Details
PA1-836
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues Q(139) E D Q F D L T V G I T D P E K I(155) of human SNX1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2302204
Product Specific Information
PA1-836 detects SNX1 in human and mouse samples. It is recommended for use with recombinant protein.
PA1-836 has been successfully used in Western blot and ICC/IF procedures. By Western blot, this antibody detects a ~60 kDa protein representing SNX1in human samples.
The PA1-836 immunogen is a synthetic peptide corresponding to residues Q(139) E D Q F D L T V G I T D P E K I(155) of human SNX1. This peptide (Cat. # PEP-286) is available for use in neutralization and control experiments.
Target Information
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1
Gene Aliases: HsT17379; SNX1; VPS5
UniProt ID: (Human) Q13596, (Mouse) Q9WV80
Entrez Gene ID: (Human) 6642, (Mouse) 56440
epidermal growth factor receptor binding
insulin receptor binding
protein binding
phosphatidylinositol binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
cadherin binding involved in cell-cell adhesion
transferrin receptor binding
leptin receptor binding
lipid binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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