Proteintech

SNX3 Polyclonal Antibody

SNX3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

SNX3 Antibody (10772-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 10772-1-AP (SNX3 antibody) at dilution of 1:25 and Alexa Fluor 594-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

10772-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SNX3 Fusion Protein Ag1160 (1-162 aa encoded by BC008444)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAETVADTR RLITKPQNLN DAYGPPSNFL EIDVSNPQTV GVGRGRFTTY EIRVKTNLPI FKLKESTVRR RYSDFEWLRS ELERESKVVV PPLPGKAFLR QLPFRGDDGI FDDNFIEERK QGLEQFINKV AGHPLAQNER CLHMFLQDEI IDKSYTPSKI RHA (1-162 aa encoded by BC008444)

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.

Oncogene

Cicek E,Circir A,Oyken M,Akbulut Caliskan O,Dioken DN,Guntekin Ergun S,Cetin-Atalay R,Sapmaz A,Ovaa H,Sahin O,Erson-Bensan AE

Sat Jan 01 00:00:00 UTC 2022

EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.

Oncogene

Cicek E,Circir A,Oyken M,Akbulut Caliskan O,Dioken DN,Guntekin Ergun S,Cetin-Atalay R,Sapmaz A,Ovaa H,Sahin O,Erson-Bensan AE

Sat Jan 01 00:00:00 UTC 2022

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications

McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Thu Sep 13 00:00:00 UTC 2018

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications

McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Thu Sep 13 00:00:00 UTC 2018

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications

McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Thu Sep 13 00:00:00 UTC 2018

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications

McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Thu Sep 13 00:00:00 UTC 2018

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.

Nature cell biology

O'Farrell F,Lobert VH,Sneeggen M,Jain A,Katheder NS,Wenzel EM,Schultz SW,Tan KW,Brech A,Stenmark H,Rusten TE

Fri Dec 01 00:00:00 UTC 2017

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.

Nature cell biology

O'Farrell F,Lobert VH,Sneeggen M,Jain A,Katheder NS,Wenzel EM,Schultz SW,Tan KW,Brech A,Stenmark H,Rusten TE

Fri Dec 01 00:00:00 UTC 2017

Label-free proteomic analysis of placental proteins during Toxoplasma gondii infection.

Journal of proteomics

Jiao F,Zhang D,Jiang M,Mi J,Liu X,Zhang H,Hu Z,Xu X,Hu X

Fri Jan 06 00:00:00 UTC 2017

Label-free proteomic analysis of placental proteins during Toxoplasma gondii infection.

Journal of proteomics

Jiao F,Zhang D,Jiang M,Mi J,Liu X,Zhang H,Hu Z,Xu X,Hu X

Fri Jan 06 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Protein SDP3; SNX 3A; sorting nexin 3A; Sorting nexin-3

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Gene Aliases: Grd19; MCOPS8; SDP3; SNX3

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UniProt ID: (Human) O60493, (Rat) Q5U211

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Entrez Gene ID: (Human) 8724, (Mouse) 54198, (Rat) 684097

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Function(s)

protein binding phosphatidylinositol-5-phosphate binding protein phosphatase binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-3,5-bisphosphate binding lipid binding phosphatidylinositol binding

Process(es)

response to bacterium membrane invagination positive regulation of neuron projection development protein transport Wnt signaling pathway protein to membrane docking regulation of Wnt signaling pathway negative regulation of protein catabolic process negative regulation of viral entry into host cell negative regulation of phagocytosis negative regulation of protein transport intralumenal vesicle formation negative regulation of early endosome to late endosome transport heme biosynthetic process transport endocytosis vesicle organization regulation of cellular protein metabolic process regulation of intracellular protein transport transferrin transport hemoglobin biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNX3 Polyclonal Antibody

SNX3 Antibody (10772-1-AP) in ICC/IF

Product Details

10772-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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