Proteintech

SNX5 Polyclonal Antibody

SNX5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SNX5 Antibody (17918-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney using 17918-1-AP (SNX5 antibody) at dilution of 1:100 (under 40x lens).

SNX5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17918-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SNX5 Fusion Protein Ag12330 (1-404 aa encoded by BC093623)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAVPELLQ QQEEDRSKLR SVSVDLNVDP SLQIDIPDAL SERDKVKFTV HTKTTLPTFQ SPEFSVTRQH EDFVWLHDTL IETTDYAGLI IPPAPTKPDF DGPREKMQKL GEGEGSMTKE EFAKMKQELE AEYLAVFKKT VSSHEVFLQR LSSHPVLSKD RNFHVFLEYD QDLSVRRKNT KEMFGGFFKS VVKSADEVLF TGVKEVDDFF EQEKNFLINY YNRIKDSCVK ADKMTRSHKN VADDYIHTAA CLHSLALEEP TVIKKYLLKV AELFEKLRKV EGRVSSDEDL KLTELLRYYM LNIEAAKDLL YRRTKALIDY ENSNKALDKA RLKSKDVKLA EAHQQECCQK FEQLSESAKE ELINFKRKRV AAFRKNLIEM SELEIKHARN NVSLLQSCID LFKNN (1-404 aa encoded by BC093623)

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein binds to fanconi anemia complementation group A protein, but its function is unknown. This gene results in two transcript variants encoding the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

iTRAQ-based quantitative proteomic analysis of the liver regeneration termination phase after partial hepatectomy in mice.

Journal of proteomics

Wu J,Liu H,Wang H,Wang Y,Cheng Q,Zhao R,Gao H,Fang L,Zhu F,Xue B

Thu Sep 15 00:00:00 UTC 2022

iTRAQ-based quantitative proteomic analysis of the liver regeneration termination phase after partial hepatectomy in mice.

Journal of proteomics

Wu J,Liu H,Wang H,Wang Y,Cheng Q,Zhao R,Gao H,Fang L,Zhu F,Xue B

Thu Sep 15 00:00:00 UTC 2022

Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.

Oxidative medicine and cellular longevity

Huang Z,Han J,Wu P,Wu C,Fan Y,Zhao L,Hao X,Chen D,Zhu M

Thu May 19 00:00:00 UTC 2022

Retromer dysfunction in amyotrophic lateral sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Pérez-Torres EJ,Utkina-Sosunova I,Mishra V,Barbuti P,De Planell-Saguer M,Dermentzaki G,Geiger H,Basile AO,Robine N,Fagegaltier D,Politi KA,Rinchetti P,Jackson-Lewis V,Harms M,Phatnani H,Lotti F,Przedborski S

Tue Jun 28 00:00:00 UTC 2022

Super-enhancer-driven Sorting Nexin 5 expression promotes dopaminergic neuronal ferroptosis in Parkinson's disease models.

Biochemical and biophysical research communications

Si W,Huang Z,Li X,Zhao L,Ji Y,Li H,Liu X,Ye S,Chen D,Liu H,Kuang W,Zhu M

Fri Aug 27 00:00:00 UTC 2021

Sorting nexin 1 loss results in increased oxidative stress and hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yang J,Asico LD,Beitelshees AL,Feranil JB,Wang X,Jones JE,Armando I,Cuevas SG,Schwartz GL,Gums JG,Chapman AB,Turner ST,Boerwinkle E,Cooper-DeHoff RM,Johnson JA,Felder RA,Weinman EJ,Zeng C,Jose PA,Villar VAM

Mon Jun 01 00:00:00 UTC 2020

A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly.

Journal of cell science

Antón Z,Betin VMS,Simonetti B,Traer CJ,Attar N,Cullen PJ,Lane JD

Wed Jul 15 00:00:00 UTC 2020

Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.

Nature cell biology

Simonetti B,Paul B,Chaudhari K,Weeratunga S,Steinberg F,Gorla M,Heesom KJ,Bashaw GJ,Collins BM,Cullen PJ

Tue Oct 01 00:00:00 UTC 2019

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications

McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Thu Sep 13 00:00:00 UTC 2018

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications

McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Thu Sep 13 00:00:00 UTC 2018

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR.

The Journal of cell biology

Simonetti B,Danson CM,Heesom KJ,Cullen PJ

Mon Nov 06 00:00:00 UTC 2017

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR.

The Journal of cell biology

Simonetti B,Danson CM,Heesom KJ,Cullen PJ

Mon Nov 06 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: FLJ10931; RP11-504H3.2; Sorting nexin-5

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Gene Aliases: 0910001N05Rik; 1810032P22Rik; AU019504; D2Ertd52e; SNX5

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UniProt ID: (Human) Q9Y5X3, (Mouse) Q9D8U8

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Entrez Gene ID: (Human) 27131, (Rat) 296199, (Mouse) 69178

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Function(s)

protein binding dynactin binding phosphatidylinositol binding protein heterodimerization activity cadherin binding involved in cell-cell adhesion lipid binding

Process(es)

intracellular protein transport endocytosis pinocytosis vesicle organization retrograde transport, endosome to Golgi regulation of macroautophagy cell-cell adhesion transport protein transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNX5 Polyclonal Antibody

SNX5 Antibody (17918-1-AP) in IHC (P)

Product Details

17918-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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