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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SNX6 Antibodies

          Proteintech

          SNX6 Polyclonal Antibody

          3 References
          View all (9) SNX6 antibodies

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          Datasheet
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          Cite SNX6 Polyclonal Antibody

          • Antibody Testing Data (15)
          SNX6 Antibody in Immunocytochemistry (ICC/IF)
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          SNX6 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 15

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          SNX6 Antibody (10114-1-AP) in ICC/IF

          Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using SNX6 antibody (Product # 10114-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SNX6 Antibody in Immunocytochemistry (ICC/IF)
          SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SNX6 Antibody in Western Blot (WB)
          SNX6 Antibody in Western Blot (WB)
          SNX6 Antibody in Western Blot (WB)
          SNX6 Antibody in Western Blot (WB)
          SNX6 Antibody in Western Blot (WB)
          SNX6 Antibody in Western Blot (WB)
          SNX6 Antibody in Flow Cytometry (Flow)
          SNX6 Antibody in Immunoprecipitation (IP)

          Product Details

          10114-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          View 2 publications 2 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:200
          -

          Flow Cytometry (Flow)

          0.2 µg/1x10^6 cells
          -

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          SNX6 Fusion Protein Ag0168 (19-290 aa encoded by BC001798)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.17 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: AIFKKTVAM HEVFLCRVAA HPILRRDLNF HVFLEYNQDL SVRGKNKKEK LEDFFKNMVK SADGVIVSGV KDVDDFFEHE RTFLLEYHNR VKDASAKSDR MTRSHKSAAD DYNRIGSSLY ALGTQDSTDI CKFFLKVSEL FDKTRKIEAR VSADEDLKLS DLLKYYLRES QAAKDLLYRR SRSLVDYENA NKALDKARAK NKDVLQAETS QQLCCQKFEK ISESAKQELI DFKTRRVAAF RKNLVELAEL ELKHAKGNLQ LLQNCLAVLN GDT (19-290 aa encoded by BC001798)

          Target Information

          SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Sorting nexin-6; TRAF4-associated factor 2; tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2

          View more View less

          Gene Aliases: 2010006G21Rik; 2610032J07Rik; 2810425K19Rik; AU018928; C85963; MSTP010; SNX6; TFAF2

          View more View less

          UniProt ID: (Human) Q9UNH7, (Mouse) Q6P8X1

          View more View less

          Entrez Gene ID: (Human) 58533, (Mouse) 72183, (Rat) 362738

          View more View less

          Function(s)
          protein binding dynactin binding phosphatidylinositol binding protein homodimerization activity protein heterodimerization activity lipid binding type I transforming growth factor beta receptor binding
          Process(es)
          intracellular protein transport endocytosis negative regulation of epidermal growth factor-activated receptor activity vesicle organization regulation of macroautophagy negative regulation of transforming growth factor beta receptor signaling pathway retrograde transport, endosome to Golgi negative regulation of transcription, DNA-templated regulation of histamine secretion by mast cell transport protein transport
          It has to be done as per old AB suggested Products section.
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