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Product Details
H00008835-M01A
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3E7
Immunogen
SOCS2 (AAH10399, 99 a.a. approximately 198 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: YQDGKFRLDS IICVKSKLKQ FDSVVHLIDY YVQMCKDKRT GPEAPRNGTV HLYLTKPLYT SAPSLQHLCR LTINKCTGAI WGLPLPTRLK DYLEEYKFQV
Target Information
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-2; Cytokine-inducible SH2 protein 2; SOCS-2; SSI-2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; Suppressor of cytokine signaling 2; suppressor of cytokine signaling-2
Gene Aliases: CIS2; Cish2; SOCS-2; SOCS2; SSI-2; SSI2; STATI2
UniProt ID: (Human) O14508
Entrez Gene ID: (Human) 8835
regulation of cell growth
negative regulation of protein kinase activity
JAK-STAT cascade
regulation of signal transduction
positive regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
response to estradiol
cellular response to hormone stimulus
negative regulation of apoptotic process
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
growth hormone receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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