Proteintech

SOCS3 Monoclonal Antibody (1G2B12)

SOCS3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SOCS3 Antibody (66797-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66797-1-Ig (SOCS3 antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

66797-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:3,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1G2B12

Immunogen

SOCS3 Fusion Protein Ag5386

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.

Journal of ethnopharmacology

Zhang Y,Wang S,Dai X,Liu T,Liu Y,Shi H,Yin J,Xu T,Zhang Y,Zhao D,Sukhorukov V,Orekhov AN,Gao S,Wang L,Zhang D

Thu Aug 10 00:00:00 UTC 2023

PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation.

Cell death & disease

Liu B,Yao X,Zhang C,Liu Y,Wei L,Huang Q,Wang M,Zhang Y,Hu D,Wu W

Mon Jan 23 00:00:00 UTC 2023

Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.

Pharmaceuticals (Basel, Switzerland)

Liu T,Gao H,Zhang Y,Wang S,Lu M,Dai X,Liu Y,Shi H,Xu T,Yin J,Gao S,Wang L,Zhang D

Mon Nov 21 00:00:00 UTC 2022

Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.

Acta pharmacologica Sinica

Yang WX,Liu Y,Zhang SM,Wang HF,Liu YF,Liu JL,Li XH,Zeng MR,Han YZ,Liu FY,Sun L,Xiao L

Tue Mar 01 00:00:00 UTC 2022

Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.

Acta pharmacologica Sinica

Yang WX,Liu Y,Zhang SM,Wang HF,Liu YF,Liu JL,Li XH,Zeng MR,Han YZ,Liu FY,Sun L,Xiao L

Tue Mar 01 00:00:00 UTC 2022

Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.

Acta pharmacologica Sinica

Yang WX,Liu Y,Zhang SM,Wang HF,Liu YF,Liu JL,Li XH,Zeng MR,Han YZ,Liu FY,Sun L,Xiao L

Tue Mar 01 00:00:00 UTC 2022

Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.

Acta pharmacologica Sinica

Yang WX,Liu Y,Zhang SM,Wang HF,Liu YF,Liu JL,Li XH,Zeng MR,Han YZ,Liu FY,Sun L,Xiao L

Tue Mar 01 00:00:00 UTC 2022

Single Treatment of Vitamin D3 Ameliorates LPS-Induced Acute Lung Injury through Changing Lung Rodentibacter abundance.

Molecular nutrition & food research

Jin A,Zhao Y,Yuan Y,Ma S,Chen J,Yang X,Lu S,Sun Q

Tue Feb 01 00:00:00 UTC 2022

Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental verification.

Journal of ethnopharmacology

Wang S,Du Q,Sun J,Geng S,Zhang Y

Wed Aug 10 00:00:00 UTC 2022

Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS).

International journal of molecular sciences

Ferrer-Donato A,Contreras A,Frago LM,Chowen JA,Fernandez-Martos CM

Fri Sep 24 00:00:00 UTC 2021

Phosphorylated nuclear factor erythroid 2-related factor 2 promotes the secretion of C-C motif chemokine ligand 2 and the recruitment of M2 macrophages.

Annals of translational medicine

Huang Z,Li X,Zhou T,Jiang Y,Shi JH

Wed Dec 01 00:00:00 UTC 2021

Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis.

International journal of molecular sciences

Barrios V,Frago LM,Canelles S,Guerra-Cantera S,Arilla-Ferreiro E,Chowen JA,Argente J

Thu Mar 11 00:00:00 UTC 2021

Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis.

International journal of molecular sciences

Barrios V,Frago LM,Canelles S,Guerra-Cantera S,Arilla-Ferreiro E,Chowen JA,Argente J

Thu Mar 11 00:00:00 UTC 2021

STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.

Frontiers in molecular biosciences

Xue Y,Zhou Y,Bao W,Fu Q,Hao H,Han L,Zhang X,Tian X,Zhang M

Fri Nov 12 00:00:00 UTC 2021

STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.

Frontiers in molecular biosciences

Xue Y,Zhou Y,Bao W,Fu Q,Hao H,Han L,Zhang X,Tian X,Zhang M

Fri Nov 12 00:00:00 UTC 2021

Autophagy Drives Galectin-1 Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular Carcinoma Progression.

Frontiers in cell and developmental biology

Davuluri GVN,Chen CC,Chiu YC,Tsai HW,Chiu HC,Chen YL,Tsai PJ,Kuo WT,Tsao N,Lin YS,Chang CP

Sat Sep 25 00:00:00 UTC 2021

Identification of the Prognostic Value Among Suppressor Of Cytokine Signaling Family Members in Kidney Renal Clear Cell Carcinoma.

Frontiers in molecular biosciences

Li C,Zhang W,Fang T,Li N,Wang Y,He L,He H

Tue Dec 21 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: CIS-3; cytokine inducible SH2-containing protein 3; Cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; MGC71791; Protein EF-10; SOCS-3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3

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Gene Aliases: ATOD4; CIS3; Cish3; EF-10; Ef10; SOCS-3; SOCS3; SSI-3; SSI3

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UniProt ID: (Human) O14543, (Mouse) O35718

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Entrez Gene ID: (Human) 9021, (Mouse) 12702

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Function(s)

protein kinase inhibitor activity protein binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SOCS3 Monoclonal Antibody (1G2B12)

SOCS3 Antibody (66797-1-IG) in IHC (P)

Product Details

66797-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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