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Invitrogen
SOCS4 Polyclonal Antibody
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FIGURE: 1 / 3
SOCS4 Antibody (PA5-119933) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of SOCS4 in Hela cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 10% negative goat serum for 15 minutes at room temperature. Cells were probed with SOCS4 Polyclonal Antibody (Product # PA5-119933) at a dilution of 1:200 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 conjugate-Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI... View More
Product Details
PA5-119933
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human SOCS4 aa 391-440
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913505
Product Specific Information
Positive Control: Rat brain tissue lysate, mouse brain tissue lysate, mouse cerebellum tissue lysate, Hela, human colon carcinoma tissue.
Subcellular Location: Phosphatidylinositol 3-kinase complex.
Target Information
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SH2 domain containing SOCS box protein; SOCS-4; SOCS-7; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 7; suppressor of cytokine signalling 4
Gene Aliases: 3110032M18Rik; A730004F22Rik; AI427843; AU015727; AU015859; SOCS4; SOCS7
UniProt ID: (Human) Q8WXH5, (Mouse) Q91ZA6
Entrez Gene ID: (Human) 122809, (Rat) 305828, (Mouse) 67296
negative regulation of protein kinase activity
negative regulation of epidermal growth factor-activated receptor activity
biological_process
protein ubiquitination
cytokine-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of JAK-STAT cascade
regulation of growth
negative regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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