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Bioss
SOCS7 Polyclonal Antibody
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Product Details
BS-20151R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SOCS7, amino acids 171-270.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NAP-4; Nck, Ash and phospholipase C binding protein; Nck, Ash and phospholipase C gamma-binding protein; NCK-associated protein 4; SH2 domain containing SOCS box protein SOCS7; SOCS-7; Suppressor of cytokine signaling 7
Gene Aliases: 2310063P06Rik; C85125; Cish7; NAP4; NCKAP4; SOCS6; SOCS7
UniProt ID: (Human) O14512, (Mouse) Q8VHQ2
Entrez Gene ID: (Human) 30837, (Rat) 287659, (Mouse) 192157
negative regulation of protein kinase activity
biological_process
insulin receptor signaling pathway
protein ubiquitination
cytokine-mediated signaling pathway
cerebral cortex radially oriented cell migration
layer formation in cerebral cortex
radial glia guided migration of Purkinje cell
intracellular signal transduction
fat cell differentiation
negative regulation of JAK-STAT cascade
regulation of growth
negative regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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