Invitrogen

SOD1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA1-18275

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues A(24) S G E P V V L S G Q I T(36) of mouse superoxide dismutase (SOD1).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1087610

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu/Zn SOD; HGNC:11179; Indophenoloxidase A (IPOA); superoxide dismutase; Superoxide Dismutase 1 (SOD1); Superoxide dismutase [Cu-Zn]

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Gene Aliases: B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1; Ipo1; Sod-1; Sod1; SODC

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UniProt ID: (Mouse) P08228, (Rat) P07632

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Entrez Gene ID: (Mouse) 20655, (Rat) 24786

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Function(s)
superoxide dismutase activity copper ion binding protein binding zinc ion binding antioxidant activity oxidoreductase activity enzyme binding protein phosphatase 2B binding identical protein binding metal ion binding Rac GTPase binding chaperone binding
Process(es)
activation of MAPK activity response to reactive oxygen species response to superoxide ovarian follicle development positive regulation of cytokine production retina homeostasis myeloid cell homeostasis glutathione metabolic process superoxide metabolic process cellular iron ion homeostasis response to oxidative stress spermatogenesis embryo implantation aging cell aging sensory perception of sound locomotory behavior anterograde axonal transport retrograde axonal transport regulation of blood pressure response to heat response to organic substance transmission of nerve impulse removal of superoxide radicals response to nutrient levels peripheral nervous system myelin maintenance positive regulation of superoxide anion generation regulation of multicellular organism growth response to drug response to hydrogen peroxide superoxide anion generation negative regulation of apoptotic process positive regulation of catalytic activity regulation of GTPase activity negative regulation of neuron apoptotic process response to ethanol negative regulation of cholesterol biosynthetic process regulation of protein kinase activity response to copper ion muscle cell cellular homeostasis response to axon injury hydrogen peroxide biosynthetic process regulation of mitochondrial membrane potential oxidation-reduction process heart contraction neurofilament cytoskeleton organization relaxation of vascular smooth muscle auditory receptor cell stereocilium organization reactive oxygen species metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway response to amphetamine double-strand break repair apoptotic DNA fragmentation response to carbon monoxide cellular response to oxidative stress cellular response to potassium ion response to antibiotic cellular response to cadmium ion cellular response to ATP response to antipsychotic drug
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