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SOD1 Monoclonal Antibody (2F10G1)

SOD1 Antibody in Immunocytochemistry (ICC/IF)

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SOD1 Antibody (67480-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293T cells using SOD1 antibody (67480-1-Ig, Clone: 2F10G1 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

SOD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

67480-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:20,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Immunocytochemistry (ICC/IF)

1:400

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

2F10G1

Immunogen

SOD1 Fusion Protein Ag28553

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pharmacologic Activation of Angiotensin-Converting Enzyme II Alleviates Diabetic Cardiomyopathy in db/db Mice by Reducing Reactive Oxidative Stress.

Diabetes & metabolism journal

Kim D,Jeong W,Kim Y,Lee J,Cho SW,Oh CM,Park R

Sat Jul 01 00:00:00 UTC 2023

Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.

Journal of biomedical science

Hung YW,Ouyang C,Ping X,Qi Y,Wang YC,Kung HJ,Ann DK

Mon May 22 00:00:00 UTC 2023

Icaritin alleviates docetaxel-induced skin injury by suppressing reactive oxygen species via estrogen receptors.

Thoracic cancer

Zou J,Xu MX,Li F,Wang YH,Li XQ,Yu DJ,Ma YJ,Zhang YY,Sun XD

Sat Jan 01 00:00:00 UTC 2022

β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wu PY,Lai SY,Su YT,Yang KC,Chau YP,Don MJ,Lu KH,Shy HT,Lai SM,Kung HN

Thu Sep 01 00:00:00 UTC 2022

Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.

Oxidative medicine and cellular longevity

Liu H,Xie J,Fan L,Xia Y,Peng X,Zhou J,Ni X

Fri Apr 15 00:00:00 UTC 2022

Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.

Stem cell research & therapy

Wang Y,Zhang Y,Chen K,Liu J,Wu D,Cheng Y,Wang H,Li Y

Sat Aug 13 00:00:00 UTC 2022

Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2.

Oxidative medicine and cellular longevity

Jin J,Lv X,Wang B,Ren C,Jiang J,Chen H,Chen X,Gu M,Pan Z,Tian N,Wu A,Sun L,Gao W,Wang X,Zhang X,Wu Y,Zhou Y

Mon Feb 07 00:00:00 UTC 2022

Frontiers in pharmacology

Ma H,Liu J,Du Y,Zhang S,Cao W,Jia Z,Gong W,Zhang A

Thu May 13 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu-Zn-superoxide dismutase; Cu/Zn SOD; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HGNC:11179; hSod1; indophenoloxidase A; Indophenoloxidase A (IPOA); SOD, soluble; superoxide dismutase; Superoxide dismutase 1; Superoxide Dismutase 1 (SOD1); Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic

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Gene Aliases: ALS; ALS1; B430204E11Rik; Cu/Zn-SOD; CuZnSOD; HEL-S-44; homodimer; hSod1; Ipo-1; Ipo1; IPOA; SOD; Sod-1; SOD1; SODC

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UniProt ID: (Pig) P04178, (Human) P00441, (Mouse) P08228, (Rat) P07632

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Entrez Gene ID: (Pig) 397036, (Human) 6647, (Mouse) 20655, (Rat) 24786

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Function(s)

superoxide dismutase activity copper ion binding protein binding zinc ion binding protein phosphatase 2B binding identical protein binding protein homodimerization activity Rac GTPase binding chaperone binding antioxidant activity oxidoreductase activity enzyme binding metal ion binding

Process(es)

activation of MAPK activity response to reactive oxygen species response to superoxide ovarian follicle development positive regulation of cytokine production retina homeostasis myeloid cell homeostasis glutathione metabolic process superoxide metabolic process cellular iron ion homeostasis response to oxidative stress spermatogenesis embryo implantation aging cell aging sensory perception of sound locomotory behavior anterograde axonal transport retrograde axonal transport regulation of blood pressure response to heat response to organic substance transmission of nerve impulse removal of superoxide radicals response to nutrient levels peripheral nervous system myelin maintenance positive regulation of superoxide anion generation regulation of multicellular organism growth response to drug response to hydrogen peroxide superoxide anion generation negative regulation of apoptotic process positive regulation of catalytic activity regulation of GTPase activity negative regulation of neuron apoptotic process response to ethanol negative regulation of cholesterol biosynthetic process regulation of protein kinase activity response to copper ion muscle cell cellular homeostasis response to axon injury hydrogen peroxide biosynthetic process regulation of mitochondrial membrane potential oxidation-reduction process heart contraction neurofilament cytoskeleton organization relaxation of vascular smooth muscle auditory receptor cell stereocilium organization reactive oxygen species metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway response to amphetamine double-strand break repair apoptotic DNA fragmentation response to carbon monoxide cellular response to oxidative stress cellular response to potassium ion response to antibiotic cellular response to cadmium ion cellular response to ATP response to antipsychotic drug placenta development platelet degranulation regulation of T cell differentiation in thymus positive regulation of apoptotic process regulation of organ growth thymus development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SOD1 Monoclonal Antibody (2F10G1)

SOD1 Antibody (67480-1-IG) in ICC/IF

Product Details

67480-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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