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Proteintech
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Immunogen sequence: DLVELKSLQ QQLSDVCYRQ ASQLEFRQNL LQAALEFHGV AQDLSQQLDG LLGMLCVDVA PADGASIQQT LKLLEEKLKS VDVGLQGLRE KGQGLLDQIS NQASWAYGKD VTIENKENVD HIQGVMEDMQ LRKQRCEDMV DVRRLKMLQM VQLFKCEEDA AQAVEWLSEL LDALLKTHIR LGDDAQETKV LLEKHRKFVD VAQSTYDYGR QLLQATVVLC QSLRCTSRSS GDTLPRLNRV WKQFTIASEE RVHRLEMAIA FHSNAEKILQ DCPEEPEAIN DEEQFDEIEA VGKSLLDRLT VPVVYPDGTE QYFGSPSDMA STAENIRDRM KLVNLKRQQL RHPEMVTTES (348-696 aa encoded by BC047578)
SESTD1 was initially identified in mutant zebrafish with defects in the spontaneous contraction and touch response as a novel gene, solo, encoding a protein containing SEC14 and spectrin repeat domains. Other experiments indicated that SESTD1 interacts with the TRPC4 and TRPC5, members of the transient receptor potential channel family, via the TRPC calmodulin- and inositol 1, 4, 5-triphosphate receptor-binding domain and is essential for efficient receptor-mediated activation of TRPC5, suggesting that SESTD1 is a novel regulator of these TRPC proteins.
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Protein Aliases: Huntingtin-interacting protein-like protein; Protein Solo; SEC14 and spectrin domains 1; SEC14 domain and spectrin repeat-containing protein 1
Gene Aliases: 1500031J16Rik; A930010O20; RGD1562244; SESTD1; SOLO; Solo/Trio8
UniProt ID: (Human) Q86VW0, (Mouse) Q80UK0
Entrez Gene ID: (Human) 91404, (Mouse) 228071, (Rat) 295678
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