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Invitrogen
SON Polyclonal Antibody
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SON Antibody (PA5-115947) in ICC/IF
Immunocytochemistry analysis of SON in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115947) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-115947
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SON(Accession P18583), corresponding to amino acid residues K1804-S1854.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900581
Product Specific Information
Antibody detects endogenous levels of total SON.
Target Information
The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BASS1; Bax antagonist selected in Saccharomyces 1; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; Protein SON; Son cell proliferation protein; SON DNA-binding protein; SON3
Gene Aliases: 2900011L12Rik; AA409051; AU067731; BASS1; C21orf50; C81487; DBP-5; DBP5; HSPC310; HSPC312; KIAA1019; mKIAA1019; NREBP; SON; SON3
UniProt ID: (Human) P18583, (Mouse) Q9QX47
Entrez Gene ID: (Human) 6651, (Rat) 304092, (Mouse) 20658
microtubule cytoskeleton organization
mRNA processing
negative regulation of apoptotic process
regulation of RNA splicing
regulation of cell cycle
mitotic cytokinesis
RNA splicing
regulation of mRNA splicing, via spliceosome
cytokinesis
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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