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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SOS1 Antibodies

          Invitrogen

          SOS1 Polyclonal Antibody

          1 Reference
          View all (11) SOS1 antibodies

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          Cite SOS1 Polyclonal Antibody

          • Antibody Testing Data (1)
          SOS1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          SOS1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          SOS1 Antibody (PA5-78174) in ICC/IF

          Immunocytochemistry-Immunofluorescence analysis of SOS1 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: SOS1 Polyclonal Antibody (Product # PA5-78174) diluted at 1:500. Blue: Hoechst 33342 staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SOS1 Antibody in Immunocytochemistry (ICC/IF)

          Product Details

          PA5-78174

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:3,000
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1:100-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human SOS1. The exact sequence is proprietary.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          2.63 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7, with 20% glycerol

          Contains

          0.025% ProClin 300

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2736647

          Product Specific Information

          Positive Control: 293T, A431, HeLa, HepG2

          Predicted Reactivity: Mouse (100%), Rat (100%)

          Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

          Target Information

          Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: G GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; Son of sevenless homolog 1; SOS-1

          View more View less

          Gene Aliases: GF1; GGF1; GINGF; HGF; NS4; SOS1

          View more View less

          UniProt ID: (Human) Q07889

          View more View less

          Entrez Gene ID: (Human) 6654

          View more View less

          Function(s)
          DNA binding guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding SH3 domain binding protein heterodimerization activity
          Process(es)
          MAPK cascade B cell homeostasis hair follicle development cardiac atrium morphogenesis pericardium morphogenesis signal transduction epidermal growth factor receptor signaling pathway Ras protein signal transduction vitellogenesis axon guidance insulin receptor signaling pathway regulation of T cell differentiation in thymus regulation of Rho protein signal transduction multicellular organism growth Fc-epsilon receptor signaling pathway ERBB2 signaling pathway regulation of T cell proliferation positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of epidermal growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway blood vessel morphogenesis leukocyte migration regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction palate development eyelid development in camera-type eye heart trabecula morphogenesis midbrain morphogenesis regulation of pro-B cell differentiation
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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