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Proteintech
SOX1 Monoclonal Antibody (1C10H2)
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Product Details
67994-1-IG150UL
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C10H2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 1; SRY box 1; SRY-box containing gene 1; SRY-related HMG-box gene 1; Transcription factor SOX-1
Gene Aliases: BB176347; Sox-1; SOX1
UniProt ID: (Human) O00570, (Mouse) P53783
Entrez Gene ID: (Human) 6656, (Mouse) 20664
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
neuron migration
lens morphogenesis in camera-type eye
chromatin organization
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
ventral spinal cord interneuron specification
forebrain neuron development
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
forebrain neuron differentiation
forebrain development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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