Invitrogen

SOX10 Recombinant Rabbit Monoclonal Antibody (2V5D6)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-42890

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2V5D6

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SOX10 (P56693).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912031

Product Specific Information

Positive test controls include: HeLa, HT-29, SH-SY5Y, Mouse large intestine, Mouse brain, Mouse heart, Rat brain, Rat heart. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: VDAKAQVKTE TAGPQGPPHY TDQPSTSQIA YTSLSLPHYG SAFPSISRPQ FDYSDHQPSG PYYGHSGQAS GLYSAFSYMG PSQRPLYTAI SDPSPSGPQS H

Target Information

SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dominant megacolon; dominant megacolon, mouse, human homolog of; MGC15649; Protein SOX-21; SRY; SRY (sex determining region Y)-box 10; SRY box 10; SRY-box containing gene 10; SRY-related HMG-box gene 10; Transcription factor SOX-10; Transcription factor SOX-M

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Gene Aliases: DOM; PCWH; Sox-10; SOX10; Sox21; WS2E; WS4; WS4C

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UniProt ID: (Human) P56693, (Rat) O55170, (Mouse) Q04888

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Entrez Gene ID: (Human) 6663, (Rat) 29361, (Mouse) 20665

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription factor binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding transcription factor binding identical protein binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding
Process(es)
in utero embryonic development neural crest cell migration positive regulation of neuroblast proliferation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter peripheral nervous system development positive regulation of gliogenesis cell differentiation melanocyte differentiation lacrimal gland development negative regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development cell maturation enteric nervous system development digestive tract morphogenesis developmental growth oligodendrocyte differentiation stem cell differentiation morphogenesis of a branching epithelium negative regulation of canonical Wnt signaling pathway transcription, DNA-templated regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis
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