Invitrogen

SOX11 Monoclonal Antibody (SOX11-C1), Biotin, eBioscience™

4 Published Figures
1 Reference
View all (22) SOX11 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

13-9773-82

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Recommended Isotype Control

Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

SOX11-C1

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2572837

Product Specific Information

Description: The monoclonal antibody SOX11-C1 (C1) recognizes human Sox11. The transcription factor Sox11 is a member of the SOX (sex determining region Y-related HMG (High Mobility Group) Box) family of proteins. Under normal conditions Sox11 is expressed in the developing central nervous system during embryogenesis and has sequence homology to Sox4. Sox11 plays a role in neuronal maturation and epithelial-mesenchymal interactions and is required for the survival of neuronal and mesenchymal progenitor cells. Sox11 is expressed in mantle cell lymphoma (MCL) and in subsets of hairy cell leukemias, Burkitt lymphomas, and B cell lymphoblastic leukemias, but is not expressed in other B cell lymphomas or in normal B lymphocytes. Sox11 is also expressed in epithelial ovarian cancer and gliomas.

Applications Reported: This SOX11-C1 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.

Applications Tested: This SOX11-C1 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded tissue using high pH antigen retrieval and can be used at less than or equal to 10 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

This intronless gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: SRY; SRY (sex-determining region Y)-box 11; SRY-related HMG-box gene 11; Transcription factor SOX-11

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Gene Aliases: MRD27; SOX11

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UniProt ID: (Human) P35716

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Entrez Gene ID: (Human) 6664

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity enhancer sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding translation factor activity, RNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development kidney development neural tube formation lens morphogenesis in camera-type eye outflow tract morphogenesis cardiac ventricle formation noradrenergic neuron differentiation transcription from RNA polymerase II promoter translation positive regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression oligodendrocyte development glial cell proliferation neural crest cell development regulation of transforming growth factor beta receptor signaling pathway spinal cord development glial cell development neuron differentiation positive regulation of BMP signaling pathway positive regulation of hippo signaling skeletal muscle cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion sympathetic nervous system development embryonic digestive tract morphogenesis embryonic skeletal system morphogenesis negative regulation of lymphocyte proliferation positive regulation of neurogenesis hard palate development soft palate development limb bud formation negative regulation of glial cell proliferation ventricular septum morphogenesis lung morphogenesis negative regulation of cell death neuroepithelial cell differentiation eyelid development in camera-type eye somite development cornea development in camera-type eye closure of optic fissure signal transduction involved in cell cycle checkpoint positive regulation of stem cell proliferation negative regulation of transcription regulatory region DNA binding positive regulation of lens epithelial cell proliferation
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