Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
SOX18 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-115951
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SOX18(Accession P35713), corresponding to amino acid residues L42-F92.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900585
Product Specific Information
Antibody detects endogenous levels of total SOX18.
Target Information
SOX18 a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ragged; SRY (sex determining region Y)-box 18; SRY box 18; SRY-box containing gene 18; Sry-related HMG-box gene 18; Transcription factor SOX-18
Gene Aliases: AI385749; HLTRS; HLTS; Ra; Ragl; Sox-18; SOX18
UniProt ID: (Human) P35713, (Mouse) P43680
Entrez Gene ID: (Human) 54345, (Rat) 311723, (Mouse) 20672
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription regulatory region DNA binding
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
vasculogenesis
in utero embryonic development
hair follicle development
vasculature development
lymphangiogenesis
heart looping
outflow tract morphogenesis
hair cycle process
embryonic heart tube development
mRNA transcription from RNA polymerase II promoter
blood vessel endothelial cell migration
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
stem cell fate specification
endocardium formation
lymphatic endothelial cell differentiation
endocardial cell differentiation
establishment of endothelial barrier
regulation of stem cell proliferation
blood vessel development
lymph vessel development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
heart development
biological_process
transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support