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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SOX2 Antibodies

          Proteintech

          SOX2 Polyclonal Antibody

          236 References
          View all (88) SOX2 antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
          Questions & Answers

          Cite SOX2 Polyclonal Antibody

          • Antibody Testing Data (19)
          SOX2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          SOX2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 19

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          SOX2 Antibody (11064-1-AP) in ICC/IF

          Confocal immunofluorescent analysis of human embronic stem cells with 11064-1-AP at dilution of 1:50. The PE shows staining with 11064-1-AP/PE. The DAPI shows nuclear staining by DAPI. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SOX2 Antibody in Immunocytochemistry (ICC/IF)
          SOX2 Antibody in Immunocytochemistry (ICC/IF)
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX2 Antibody in Immunohistochemistry (IHC)
          SOX2 Antibody in Immunohistochemistry (IHC)
          SOX2 Antibody in Immunohistochemistry (IHC)
          SOX2 Antibody in Immunohistochemistry (IHC)
          SOX2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          SOX2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          SOX2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          SOX2 Antibody in Western Blot (WB)
          SOX2 Antibody in Western Blot (WB)

          Product Details

          11064-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:2,000-1:20,000
          View 137 publications 137 publications

          Immunohistochemistry (IHC)

          -
          View 36 publications 36 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 58 publications 58 publications

          Flow Cytometry (Flow)

          -
          View 1 publication 1 publication

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication

          Not applicable (N/A)

          -
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat, Zebrafish

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          SOX2 Fusion Protein Ag1530 (59-118 aa encoded by BC013923)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.4 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          This antibody is a rabbit polyclonal antibody raised against an internal region of human SOX2. a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation. Sox2-expressing neural stem cells in the subgranular zone (SGZ), a well-known stem cell niche of the adult brain.

          Immunogen sequence: MAQENPKMH NSEISKRLGA EWKLLSETEK RPFIDEAKRL RALHMKEHPD YKYRPRRKTK T (59-118 aa encoded by BC013923)

          Target Information

          SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

          View more View less

          Gene Aliases: ANOP3; cb236; lcc; MCOPS3; RGD1565646; Sox-2; SOX2; soxp; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389

          View more View less

          UniProt ID: (Human) P48431, (Mouse) P48432, (Zebrafish) Q6P0E1

          View more View less

          Entrez Gene ID: (Human) 6657, (Rat) 499593, (Mouse) 20674, (Zebrafish) 378723

          View more View less

          Function(s)
          transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function chromatin binding transcription factor binding protein heterodimerization activity chromatin DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance multicellular organism development central nervous system development cell proliferation epithalamus development pineal gland development cell differentiation neuron differentiation regeneration fin regeneration eye morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity inner ear receptor cell development otic vesicle development otic placode development cell fate specification positive regulation of neuroblast proliferation regulation of transcription from RNA polymerase II promoter sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis transcription, DNA-templated
          It has to be done as per old AB suggested Products section.
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