Product References
Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang C,Zhang L,Cao M,Fu Z,Wang H,Zhang S,Zhu K,Hou Z,Cui J,Yue P,Guo H,Zhang T
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Western Blot
Thu Jun 01 00:00:00 UTC 2023
Non-muscle myosins control radial glial basal endfeet to mediate interneuron organization.
PLoS biology
D'Arcy BR,Lennox AL,Manso Musso C,Bracher A,Escobar-Tomlienovich C,Perez-Sanchez S,Silver DL
14-9811-82 was used in Immunohistochemistry to demonstrate the utility of in vivo proximity labeling for dissecting local control of complex systems and reveals new mechanisms for dictating RGC integrity and cortical architecture.
Wed Feb 01 00:00:00 UTC 2023
Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes.
Human molecular genetics
Flex E,Albadri S,Radio FC,Cecchetti S,Lauri A,Priolo M,Kissopoulos M,Carpentieri G,Fasano G,Venditti M,Magliocca V,Bellacchio E,Welch CL,Colombo PC,Kochav SM,Chang R,Barrick R,Trivisano M,Micalizzi A,Borghi R,Messina E,Mancini C,Pizzi S,De Santis F,Rosello M,Specchio N,Compagnucci C,McWalter K,Chung WK,Del Bene F,Tartaglia M
14-9811-82 was used in Immunohistochemistry to report three dominantly acting KIF5B variants (p.Asn255del, p.Leu498Pro and p.Leu537Pro) resulting in a clinically wide phenotypic spectrum, ranging from dilated cardiomyopathy with adult-onset ophthalmoplegia and progressive skeletal myopathy to a neurodevelopmental condition characterized by severe hypotonia with or without seizures.
Fri Jan 13 00:00:00 UTC 2023
Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells.
Cellular and molecular life sciences : CMLS
Eenjes E,Benthem F,Boerema-de Munck A,Buscop-van Kempen M,Tibboel D,Rottier RJ
14-9811-82 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that precursor NE cells start to develop in the SOX2 + SOX21 + airway region and that SOX21 suppresses the differentiation of airway progenitors to precursor NE cells.
Fri Mar 03 00:00:00 UTC 2023
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma.
Nature
Hu J,Sánchez-Rivera FJ,Wang Z,Johnson GN,Ho YJ,Ganesh K,Umeda S,Gan S,Mujal AM,Delconte RB,Hampton JP,Zhao H,Kottapalli S,de Stanchina E,Iacobuzio-Donahue CA,Pe'er D,Lowe SW,Sun JC,Massagué J
14-9811-82 was used in Immunohistochemistry to identify cancer cell-intrinsic determinants of immune reactivity during exit from dormancy.
Sat Apr 01 00:00:00 UTC 2023
Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo.
Nature communications
Hawdon A,Geoghegan ND,Mohenska M,Elsenhans A,Ferguson C,Polo JM,Parton RG,Zenker J
14-9811-82 was used in Immunohistochemistry to identify a paradigm for the spatiotemporal regulation of post-transcriptional gene expression governing mammalian preimplantation embryogenesis and cell fate.
Tue May 30 00:00:00 UTC 2023
A gastruloid model of the interaction between embryonic and extra-embryonic cell types.
Journal of tissue engineering
Bérenger-Currias NM,Mircea M,Adegeest E,van den Berg PR,Feliksik M,Hochane M,Idema T,Tans SJ,Semrau S
14-9811-82 was used in Immunohistochemistry and Immunocytochemistry to establish XEGs to explore heterotypic cellular interactions and their developmental consequences in vitro.
Sat Jul 16 00:00:00 UTC 2022
A gastruloid model of the interaction between embryonic and extra-embryonic cell types.
Journal of tissue engineering
Bérenger-Currias NM,Mircea M,Adegeest E,van den Berg PR,Feliksik M,Hochane M,Idema T,Tans SJ,Semrau S
14-9811-82 was used in Immunohistochemistry and Immunocytochemistry to establish XEGs to explore heterotypic cellular interactions and their developmental consequences in vitro.
Sat Jul 16 00:00:00 UTC 2022
Formation of three-dimensional cell aggregates expressing lens-specific proteins in various cultures of human iris-derived tissue cells and iPS cells.
Experimental and therapeutic medicine
Hiramatsu N,Yamamoto N,Kato Y,Nagai N,Isogai S,Imaizumi K
14-9811-82 was used in Immunocytochemistry-immunoflourescence to suggest that the cell-cell interaction facilitated by cell aggregation may have a critical role in enabling highly efficient differentiation of LECs.
Mon Aug 01 00:00:00 UTC 2022
The Effect of Infant Gastric Digestion on Human Maternal Milk Cells.
Molecular nutrition & food research
Doerfler R,Melamed JR,Whitehead KA
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Flow Cytometry
Sat Oct 01 00:00:00 UTC 2022
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential.
Developmental cell
Frederico B,Martins I,Chapela D,Gasparrini F,Chakravarty P,Ackels T,Piot C,Almeida B,Carvalho J,Ciccarelli A,Peddie CJ,Rogers N,Briscoe J,Guillemot F,Schaefer AT,Saúde L,Reis e Sousa C
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunohistochemistry
Mon Aug 22 00:00:00 UTC 2022
Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells.
Current protocols
Bulut M,Vila Cuenca M,de Graaf M,van den Hil FE,Mummery CL,Orlova VV
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Flow Cytometry
Sat Oct 01 00:00:00 UTC 2022
Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis.
International journal of molecular sciences
Belgacemi R,Danopoulos S,Deutsch G,Glass I,Dormoy V,Bellusci S,Al Alam D
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunohistochemistry
Mon May 09 00:00:00 UTC 2022
Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis.
International journal of molecular sciences
Belgacemi R,Danopoulos S,Deutsch G,Glass I,Dormoy V,Bellusci S,Al Alam D
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunohistochemistry
Mon May 09 00:00:00 UTC 2022
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Acta neuropathologica communications
Lambert E,Saha O,Soares Landeira B,Melo de Farias AR,Hermant X,Carrier A,Pelletier A,Gadaut J,Davoine L,Dupont C,Amouyel P,Bonnefond A,Lafont F,Abdelfettah F,Verstreken P,Chapuis J,Barois N,Delahaye F,Dermaut B,Lambert JC,Costa MR,Dourlen P
14-9811-82 was used in Immunohistochemistry, Immunocytochemistry to demonstrate that the AD susceptibility gene BIN1, and especially BIN1iso1, contributes to early-endosome size deregulation, which is an early pathophysiological hallmark of AD pathology.
Sat Jan 08 00:00:00 UTC 2022
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Acta neuropathologica communications
Lambert E,Saha O,Soares Landeira B,Melo de Farias AR,Hermant X,Carrier A,Pelletier A,Gadaut J,Davoine L,Dupont C,Amouyel P,Bonnefond A,Lafont F,Abdelfettah F,Verstreken P,Chapuis J,Barois N,Delahaye F,Dermaut B,Lambert JC,Costa MR,Dourlen P
14-9811-82 was used in Immunohistochemistry, Immunocytochemistry to demonstrate that the AD susceptibility gene BIN1, and especially BIN1iso1, contributes to early-endosome size deregulation, which is an early pathophysiological hallmark of AD pathology.
Sat Jan 08 00:00:00 UTC 2022
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
Acta neuropathologica communications
Lambert E,Saha O,Soares Landeira B,Melo de Farias AR,Hermant X,Carrier A,Pelletier A,Gadaut J,Davoine L,Dupont C,Amouyel P,Bonnefond A,Lafont F,Abdelfettah F,Verstreken P,Chapuis J,Barois N,Delahaye F,Dermaut B,Lambert JC,Costa MR,Dourlen P
14-9811-82 was used in Immunohistochemistry, Immunocytochemistry to demonstrate that the AD susceptibility gene BIN1, and especially BIN1iso1, contributes to early-endosome size deregulation, which is an early pathophysiological hallmark of AD pathology.
Sat Jan 08 00:00:00 UTC 2022
Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.
eLife
Hoye ML,Calviello L,Poff AJ,Ejimogu NE,Newman CR,Montgomery MD,Ou J,Floor SN,Silver DL
14-9811-82 was used in Immunohistochemistry to reveal invaluable new insights into the etiology of DDX3X syndrome, implicating dysregulated progenitor cell cycle dynamics and translation as pathogenic mechanisms.
Tue Jun 28 00:00:00 UTC 2022
Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo.
Nature communications
Benetti N,Gouil Q,Tapia Del Fierro A,Beck T,Breslin K,Keniry A,McGlinn E,Blewitt ME
14-9811-82 was used in Immunocytochemistry-immunofluorescence to report that the epigenetic regulator SMCHD1 has a maternal effect on Hox gene expression and skeletal patterning.
Mon Jul 25 00:00:00 UTC 2022
A minimal-complexity light-sheet microscope maps network activity in 3D neuronal systems.
Scientific reports
Wysmolek PM,Kiessler FD,Salbaum KA,Shelton ER,Sonntag SM,Serwane F
14-9811-82 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to create a 3D connectivity map of a stem cell derived neuron spheroid by imaging its activity.
Mon Nov 28 00:00:00 UTC 2022
Progenitor potential of lung epithelial organoid cells in a transplantation model.
Cell reports
Louie SM,Moye AL,Wong IG,Lu E,Shehaj A,Garcia-de-Alba C,Ararat E,Raby BA,Lu B,Paschini M,Bronson RT,Kim CF
14-9811-82 was used in Immunohistochemistry to interrogate lung progenitor cell potential and model transitional cell states relevant to pathogenic features of lung disease in vivo.
Tue Apr 12 00:00:00 UTC 2022
Epithelial Wntless regulates postnatal alveologenesis.
Development (Cambridge, England)
Fang Y,Shao H,Wu Q,Wong NC,Tsong N,Sime PJ,Que J
14-9811-82 was used in Immunohistochemistry-immunofluorescence to provide initial evidence that epithelial-derived Wnts are crucial for the differentiation of the surrounding mesenchyme during early postnatal alveologenesis.
Sat Jan 01 00:00:00 UTC 2022
Integrated age-related immunohistological changes occur in human olfactory epithelium and olfactory bulb.
The Journal of comparative neurology
Fitzek M,Patel PK,Solomon PD,Lin B,Hummel T,Schwob JE,Holbrook EH
14-9811-82 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to characterize changes associated with age in the peripheral olfactory system, by in-depth analysis of the OE and its neuronal projections onto the olfactory bulb (OB) as a function of age.
Mon Aug 01 00:00:00 UTC 2022
Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation.
Acta neuropathologica communications
Lakis NS,Brodsky AS,Karashchuk G,Audesse AJ,Yang D,Sturtevant A,Lombardo K,Wong IY,Webb AE,Anthony DC
14-9811-82 was used in Immunohistochemistry to support the concept that the presence of a high stem cell phenotype in GBM, as marked by expression of SOX2 or CD133, may be associated with the clinical response to treatment.
Fri Nov 04 00:00:00 UTC 2022
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Cell stem cell
Kinoshita M,Barber M,Mansfield W,Cui Y,Spindlow D,Stirparo GG,Dietmann S,Nichols J,Smith A
14-9811-82 was used in Immunocytochemistry to suggest that formative stem cells which respond directly to germ cell induction can be cultured from mice and humans.
Thu Mar 04 00:00:00 UTC 2021
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Cell stem cell
Kinoshita M,Barber M,Mansfield W,Cui Y,Spindlow D,Stirparo GG,Dietmann S,Nichols J,Smith A
14-9811-82 was used in Immunocytochemistry to suggest that formative stem cells which respond directly to germ cell induction can be cultured from mice and humans.
Thu Mar 04 00:00:00 UTC 2021
Visualization of individual cell division history in complex tissues using iCOUNT.
Cell stem cell
Denoth-Lippuner A,Jaeger BN,Liang T,Royall LN,Chie SE,Buthey K,Machado D,Korobeynyk VI,Kruse M,Munz CM,Gerbaulet A,Simons BD,Jessberger S
14-9811-82 was used in Immunohistochemistry to characterize the molecular consequences of repeated cell divisions of stem cells that allows an analysis of the cellular principles underlying tissue formation, homeostasis, and repair by inducible cell division counter (iCOUNT).
Thu Nov 04 00:00:00 UTC 2021
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Developmental cell
Kasashima H,Duran A,Martinez-Ordoñez A,Nakanishi Y,Kinoshita H,Linares JF,Reina-Campos M,Kudo Y,L'Hermitte A,Yashiro M,Ohira M,Bao F,Tauriello DVF,Batlle E,Diaz-Meco MT,Moscat J
14-9811-82 was used in Immunohistochemistry to explore the transcriptional mechanisms regulating cancer-associated fibroblasts in promoting tumour malignancy.
Mon Jan 11 00:00:00 UTC 2021
Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor-initiating cells.
Brain pathology (Zurich, Switzerland)
Dzikowski L,Mirzaei R,Sarkar S,Kumar M,Bose P,Bellail A,Hao C,Yong VW
14-9811-82 was used in Immunocytochemistry to investigate the expression of ECM molecules in GBM patients by mining the transcriptomic databases and staining human GBM specimens.
Wed Sep 01 00:00:00 UTC 2021
Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor-initiating cells.
Brain pathology (Zurich, Switzerland)
Dzikowski L,Mirzaei R,Sarkar S,Kumar M,Bose P,Bellail A,Hao C,Yong VW
14-9811-82 was used in Immunocytochemistry to investigate the expression of ECM molecules in GBM patients by mining the transcriptomic databases and staining human GBM specimens.
Wed Sep 01 00:00:00 UTC 2021
Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation.
Development (Cambridge, England)
Austin SHL,Gabarró-Solanas R,Rigo P,Paun O,Harris L,Guillemot F,Urbán N
14-9811-82 was used in Immunohistochemistry and Immunocytochemistry to indicate that, although neural stem cells (NSCs) do respond to Wnt/β-catenin stimulation in a dose-dependent and state-specific manner, Wnt/β-catenin signalling is not cell-autonomously required to maintain NSC homeostasis, which reconciles some of the contradictions in the literature as to the role of Wnt/β-catenin signalling in adult hippocampal NSCs.
Fri Oct 15 00:00:00 UTC 2021
Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation.
Development (Cambridge, England)
Austin SHL,Gabarró-Solanas R,Rigo P,Paun O,Harris L,Guillemot F,Urbán N
14-9811-82 was used in Immunohistochemistry and Immunocytochemistry to indicate that, although neural stem cells (NSCs) do respond to Wnt/β-catenin stimulation in a dose-dependent and state-specific manner, Wnt/β-catenin signalling is not cell-autonomously required to maintain NSC homeostasis, which reconciles some of the contradictions in the literature as to the role of Wnt/β-catenin signalling in adult hippocampal NSCs.
Fri Oct 15 00:00:00 UTC 2021
Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation.
Development (Cambridge, England)
Austin SHL,Gabarró-Solanas R,Rigo P,Paun O,Harris L,Guillemot F,Urbán N
14-9811-82 was used in Immunohistochemistry and Immunocytochemistry to indicate that, although neural stem cells (NSCs) do respond to Wnt/β-catenin stimulation in a dose-dependent and state-specific manner, Wnt/β-catenin signalling is not cell-autonomously required to maintain NSC homeostasis, which reconciles some of the contradictions in the literature as to the role of Wnt/β-catenin signalling in adult hippocampal NSCs.
Fri Oct 15 00:00:00 UTC 2021
Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Huang TW,Iyer AA,Manalo JM,Woo J,Bosquez Huerta NA,McGovern MM,Schrewe H,Pereira FA,Groves AK,Ohlemiller KK,Deneen B
14-9811-82 was used in Immunohistochemistry (Frozen) to study the effects of temporal conditional deletion of Med12 in astrocytes in the adult CNS.
Wed Aug 25 00:00:00 UTC 2021
Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency.
Disease models & mechanisms
Niceforo A,Marioli C,Colasuonno F,Petrini S,Massey K,Tartaglia M,Bertini E,Moreno S,Compagnucci C
14-9811 was used in Immunocytochemistry-Immunofluorescence to show that RF administration resulted in partially improved cytoskeletal features in patients' iPSCs and MNs.
Tue Jan 19 00:00:00 UTC 2021
The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.
The FEBS journal
Hosoya M,Fujioka M,Murayama AY,Okano H,Ogawa K
14-9811 was used in Immunohistochemistry-immunofluorescence to support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
Fri Jan 01 00:00:00 UTC 2021
An epilepsy-associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model.
Journal of neuroscience research
Ahn LY,Coatti GC,Liu J,Gumus E,Schaffer AE,Miranda HC
14-9811 was used in Immunocytochemistry to investigate the molecular pathogenesis of ACTL6B p.(Val421_Cys425del) using in silico 3D protein modeling predictions and patient-specific induced pluripotent stem cell-derived neurons.
Fri Jan 01 00:00:00 UTC 2021
An epilepsy-associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model.
Journal of neuroscience research
Ahn LY,Coatti GC,Liu J,Gumus E,Schaffer AE,Miranda HC
14-9811 was used in Immunocytochemistry to investigate the molecular pathogenesis of ACTL6B p.(Val421_Cys425del) using in silico 3D protein modeling predictions and patient-specific induced pluripotent stem cell-derived neurons.
Fri Jan 01 00:00:00 UTC 2021
Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.
Journal of experimental & clinical cancer research : CR
Liu C,Pan Z,Chen Q,Chen Z,Liu W,Wu L,Jiang M,Lin W,Zhang Y,Lin W,Zhou R,Zhao L
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Flow Cytometry
Wed Sep 22 00:00:00 UTC 2021
Quantitative analysis of signaling responses during mouse primordial germ cell specification.
Biology open
Morgani SM,Hadjantonakis AK
14-9811-82 was used in Immunocytochemistry-immunofluorescence to investigate the signalling response of BMP, MAPK and WNT in primordial germ cells of mice.
Sat May 15 00:00:00 UTC 2021
Quantitative analysis of signaling responses during mouse primordial germ cell specification.
Biology open
Morgani SM,Hadjantonakis AK
14-9811-82 was used in Immunocytochemistry-immunofluorescence to investigate the signalling response of BMP, MAPK and WNT in primordial germ cells of mice.
Sat May 15 00:00:00 UTC 2021
Modulating mesendoderm competence during human germ layer differentiation.
Cell reports
Valcourt JR,Huang RE,Kundu S,Venkatasubramanian D,Kingston RE,Ramanathan S
14-9811-82 was used in Immunocytochemistry to conclude that the ability of the underlying gene regulatory network to modulate competence is essential for understanding human development and controlling the fate choices of stem cells in vitro.
Tue Nov 09 00:00:00 UTC 2021
Modulating mesendoderm competence during human germ layer differentiation.
Cell reports
Valcourt JR,Huang RE,Kundu S,Venkatasubramanian D,Kingston RE,Ramanathan S
14-9811-82 was used in Immunocytochemistry to conclude that the ability of the underlying gene regulatory network to modulate competence is essential for understanding human development and controlling the fate choices of stem cells in vitro.
Tue Nov 09 00:00:00 UTC 2021
Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype.
Nature communications
Kojic M,Gawda T,Gaik M,Begg A,Salerno-Kochan A,Kurniawan ND,Jones A,Drożdżyk K,Kościelniak A,Chramiec-Głąbik A,Hediyeh-Zadeh S,Kasherman M,Shim WJ,Sinniah E,Genovesi LA,Abrahamsen RK,Fenger CD,Madsen CG,Cohen JS,Fatemi A,Stark Z,Lunke S,Lee J,Hansen JK,Boxill MF,Keren B,Marey I,Saenz MS,Brown K,Alexander SA,Mureev S,Batzilla A,Davis MJ,Piper M,Bodén M,Burne THJ,Palpant NJ,Møller RS,Glatt S,Wainwright BJ
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunohistochemistry
Tue May 11 00:00:00 UTC 2021
Induction of inverted morphology in brain organoids by vertical-mixing bioreactors.
Communications biology
Suong DNA,Imamura K,Inoue I,Kabai R,Sakamoto S,Okumura T,Kato Y,Kondo T,Yada Y,Klein WL,Watanabe A,Inoue H
14-9811-82 was used in Immunohistochemistry to suggest that controlling fluid dynamics by biomechanical engineering can direct stem cell differentiation of brain organoids, and that inverted brain organoids will be applicable for studying human brain development and disorders in the future.
Fri Oct 22 00:00:00 UTC 2021
Induction of inverted morphology in brain organoids by vertical-mixing bioreactors.
Communications biology
Suong DNA,Imamura K,Inoue I,Kabai R,Sakamoto S,Okumura T,Kato Y,Kondo T,Yada Y,Klein WL,Watanabe A,Inoue H
14-9811-82 was used in Immunohistochemistry to suggest that controlling fluid dynamics by biomechanical engineering can direct stem cell differentiation of brain organoids, and that inverted brain organoids will be applicable for studying human brain development and disorders in the future.
Fri Oct 22 00:00:00 UTC 2021
The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.
eLife
Morgani SM,Su J,Nichols J,Massagué J,Hadjantonakis AK
14-9811 was used in Immunohistochemistry to determine that ras-responsive element-binding protein 1 is essential for mouse embryonic development, with a possible role in cancer and diseases involving loss of epithelial integrity.
Fri Apr 30 00:00:00 UTC 2021
The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.
eLife
Morgani SM,Su J,Nichols J,Massagué J,Hadjantonakis AK
14-9811 was used in Immunohistochemistry to determine that ras-responsive element-binding protein 1 is essential for mouse embryonic development, with a possible role in cancer and diseases involving loss of epithelial integrity.
Fri Apr 30 00:00:00 UTC 2021
PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway.
Science advances
Mirzaei R,Gordon A,Zemp FJ,Kumar M,Sarkar S,Luchman HA,Bellail AC,Hao C,Mahoney DJ,Dunn JF,Bose P,Yong VW
14-9811-82 was used in Immunohistochemistry (Paraffin), Immunocytochemistry to point to a critical role for PD-1 in BTICs and uncover a nonimmune resistance mechanism of patients with glioblastoma to PD-1- or PD-L1-blocking therapies.
Fri Nov 05 00:00:00 UTC 2021
PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway.
Science advances
Mirzaei R,Gordon A,Zemp FJ,Kumar M,Sarkar S,Luchman HA,Bellail AC,Hao C,Mahoney DJ,Dunn JF,Bose P,Yong VW
14-9811-82 was used in Immunohistochemistry (Paraffin), Immunocytochemistry to point to a critical role for PD-1 in BTICs and uncover a nonimmune resistance mechanism of patients with glioblastoma to PD-1- or PD-L1-blocking therapies.
Fri Nov 05 00:00:00 UTC 2021
Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.
Cells
Siljee S,Buchanan O,Brasch HD,Bockett N,Patel J,Paterson E,Purdie GL,Davis PF,Itinteang T,Tan ST
14-9811-82 was used in Immunohistochemistry to investigate the expression of components of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations in metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC).
Wed Jan 27 00:00:00 UTC 2021
Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.
Cells
Siljee S,Buchanan O,Brasch HD,Bockett N,Patel J,Paterson E,Purdie GL,Davis PF,Itinteang T,Tan ST
14-9811-82 was used in Immunohistochemistry to investigate the expression of components of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations in metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC).
Wed Jan 27 00:00:00 UTC 2021
Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells.
Cells
Soni A,Klütsch D,Hu X,Houtman J,Rund N,McCloskey A,Mertens J,Schafer ST,Amin H,Toda T
14-9811-82 was used in Immunocytochemistry to demonstrate that induced neurons (NPC-iNs) by this method make synaptic connections, elicit neuronal activity-dependent cellular responses, and develop functional neuronal networks.
Mon Jul 26 00:00:00 UTC 2021
Spatially Organized Differentiation of Mouse Pluripotent Stem Cells on Micropatterned Surfaces.
Methods in molecular biology (Clifton, N.J.)
Morgani SM,Hadjantonakis AK
14-9811-82 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to describe a protocol to differentiate mouse PSCs in a spatially organized manner on micropatterned surfaces.
Tue Mar 30 00:00:00 UTC 2021
TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1.
Nature
Su J,Morgani SM,David CJ,Wang Q,Er EE,Huang YH,Basnet H,Zou Y,Shu W,Soni RK,Hendrickson RC,Hadjantonakis AK,Massagué J
14-9811 was used in Immunofluorescence on wholemounted tissues to reveal how TGF-β and RAS-MAPK signals acting jointly through SMAD and RREB1 transcription factors trigger EMTs in different contexts.
Wed Jan 01 00:00:00 UTC 2020
Initiation of a conserved trophectoderm program in human, cow and mouse embryos.
Nature
Gerri C,McCarthy A,Alanis-Lobato G,Demtschenko A,Bruneau A,Loubersac S,Fogarty NME,Hampshire D,Elder K,Snell P,Christie L,David L,Van de Velde H,Fouladi-Nashta AA,Niakan KK
14-9811-82 was used in Immunocytochemistry to demonstrate that inhibition of aPKC by small-molecule pharmacological modulation or Trim-Away protein depletion impairs TE initiation at the morula stage.
Sun Nov 01 00:00:00 UTC 2020
Identification of Sox2 and NeuN Double-Positive Cells in the Mouse Hypothalamic Arcuate Nucleus and Their Reduction in Number With Aging.
Frontiers in aging neuroscience
Sugiura A,Shimizu T,Kameyama T,Maruo T,Kedashiro S,Miyata M,Mizutani K,Takai Y
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunocytochemistry
Tue Mar 30 00:00:00 UTC 2021
Embryonic disc formation following post-hatching bovine embryo development in vitro.
Reproduction (Cambridge, England)
Ramos-Ibeas P,Lamas-Toranzo I,Martínez-Moro Á,de Frutos C,Quiroga AC,Zurita E,Bermejo-Álvarez P
14-9811-82 was used in Immunohistochemistry to support embryonic disc formation.
Thu Oct 01 00:00:00 UTC 2020
Embryonic disc formation following post-hatching bovine embryo development in vitro.
Reproduction (Cambridge, England)
Ramos-Ibeas P,Lamas-Toranzo I,Martínez-Moro Á,de Frutos C,Quiroga AC,Zurita E,Bermejo-Álvarez P
14-9811-82 was used in Immunohistochemistry to support embryonic disc formation.
Thu Oct 01 00:00:00 UTC 2020
Keratin 13 deficiency causes white sponge nevus in mice.
Developmental biology
Simonson L,Vold S,Mowers C,Massey RJ,Ong IM,Longley BJ,Chang H
14-9811-82 was used in Immunohistochemistry to determine whether there is a causal relationship between keratin 13 mutations and white sponge nevus and what the underlying mechanisms might be.
Tue Dec 01 00:00:00 UTC 2020
Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by the nucleosome remodelling and deacetylation complex.
Stem cell research
Ragheb R,Gharbi S,Cramard J,Ogundele O,Kloet SL,Burgold T,Vermeulen M,Reynolds N,Hendrich B
14-9811-82 was used in Immunocytochemistry to reveal that failure to properly fine-tune gene expression and/or to reduce transcriptional noise through the action of a highly conserved chromatin remodeller can have different consequences in human and mouse pluripotent stem cells.
Wed Jul 01 00:00:00 UTC 2020
Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellular and Genomic Landscape of Atypical Teratoid/Rhabdoid.
Cancers
Hoffman MM,Zylla JS,Bhattacharya S,Calar K,Hartman TW,Bhardwaj RD,Miskimins WK,de la Puente P,Gnimpieba EZ,Messerli SM
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Flow Cytometry
Mon Mar 23 00:00:00 UTC 2020
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Viruses
Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U
14-9811 was used in Immunohistochemistry to study whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Mon May 25 00:00:00 UTC 2020
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Viruses
Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U
14-9811 was used in Immunohistochemistry to study whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Mon May 25 00:00:00 UTC 2020
Microfluidic platform for 3D cell culture with live imaging and clone retrieval.
Lab on a chip
Mulas C,Hodgson AC,Kohler TN,Agley CC,Humphreys P,Kleine-Brüggeney H,Hollfelder F,Smith A,Chalut KJ
14-9811-82 was used in Immunocytochemistry to present a highly flexible 3D cell encapsulation and microfluidic platform that enables both monitoring of cellular dynamics and retrieval for molecular and functional assays.
Tue Jul 14 00:00:00 UTC 2020
Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System.
Life (Basel, Switzerland)
Siljee S,Pilkington T,Brasch HD,Bockett N,Patel J,Paterson E,Davis PF,Tan ST
14-9811 was used in Immunohistochemistry-immunofluorescence to investigate expression of the RAS by the CSC subpopulations in human head and neck metastatic malignant melanoma (HNmMM) tissue samples and HNmMM-derived primary cell lines.
Mon Nov 02 00:00:00 UTC 2020
Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System.
Life (Basel, Switzerland)
Siljee S,Pilkington T,Brasch HD,Bockett N,Patel J,Paterson E,Davis PF,Tan ST
14-9811 was used in Immunohistochemistry-immunofluorescence to investigate expression of the RAS by the CSC subpopulations in human head and neck metastatic malignant melanoma (HNmMM) tissue samples and HNmMM-derived primary cell lines.
Mon Nov 02 00:00:00 UTC 2020
Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation.
Stem cells (Dayton, Ohio)
Cameron BD,Traver G,Roland JT,Brockman AA,Dean D,Johnson L,Boyd K,Ihrie RA,Freeman ML
14-9811-82 was used in Immunohistochemistry (Paraffin) to demonstrate that murine type B neural stem cells residing in the ventricular-subventricular zone are tolerant of standard chemoradiation therapy, supporting a dose escalation strategy for treatment of very aggressive glioblastoma.
Sun Dec 01 00:00:00 UTC 2019
Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells.
Development (Cambridge, England)
Deathridge J,Antolović V,Parsons M,Chubb JR
14-9811-82 was used in Immunocytochemistry to suggest a combination of cell lineage and niche contributes to the absolute level of ERK signalling in mouse ESCs.
Mon Jun 03 00:00:00 UTC 2019
3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.
Cell stem cell
Zhang Y,Yang Y,Jiang M,Huang SX,Zhang W,Al Alam D,Danopoulos S,Mori M,Chen YW,Balasubramanian R,Chuva de Sousa Lopes SM,Serra C,Bialecka M,Kim E,Lin S,Toste de Carvalho ALR,Riccio PN,Cardoso WV,Zhang X,Snoeck HW,Que J
14-9811 was used in Immunocytochemistry-immunoflourescence to provide an efficient approach to generate EPCs, and offer a model system to study the regulatory mechanisms underlying development of the human esophagus.
Thu Oct 04 00:00:00 UTC 2018
Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways.
Developmental cell
Yang Y,Riccio P,Schotsaert M,Mori M,Lu J,Lee DK,García-Sastre A,Xu J,Cardoso WV
14-9811-82 was used in Immunohistochemistry to elucidate key aspects in the establishment of regionally distinct adult stem cell pools in the respiratory system, potentially with relevance to other organs.
Mon Mar 26 00:00:00 UTC 2018
Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.
eLife
Morgani SM,Metzger JJ,Nichols J,Siggia ED,Hadjantonakis AK
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunofluorescence
Wed Feb 07 00:00:00 UTC 2018
Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.
eLife
Morgani SM,Metzger JJ,Nichols J,Siggia ED,Hadjantonakis AK
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunofluorescence
Wed Feb 07 00:00:00 UTC 2018
BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.
Nature communications
Lazarus KA,Hadi F,Zambon E,Bach K,Santolla MF,Watson JK,Correia LL,Das M,Ugur R,Pensa S,Becker L,Campos LS,Ladds G,Liu P,Evan GI,McCaughan FM,Le Quesne J,Lee JH,Calado D,Khaled WT
Published figure using SOX2 monoclonal antibody (Product # 14-9811-82) in Immunofluorescence
Mon Aug 20 00:00:00 UTC 2018
One-step generation of conditional and reversible gene knockouts.
Nature methods
Andersson-Rolf A,Mustata RC,Merenda A,Kim J,Perera S,Grego T,Andrews K,Tremble K,Silva JC,Fink J,Skarnes WC,Koo BK
14-9811 was used in Western Blotting and ICC/IF to present CRISPR-FLIP, a method providing efficient, rapid and scalable method for biallelic conditional gene knockouts.
Wed Mar 01 00:00:00 UTC 2017
One-step generation of conditional and reversible gene knockouts.
Nature methods
Andersson-Rolf A,Mustata RC,Merenda A,Kim J,Perera S,Grego T,Andrews K,Tremble K,Silva JC,Fink J,Skarnes WC,Koo BK
14-9811 was used in Western Blotting and ICC/IF to present CRISPR-FLIP, a method providing efficient, rapid and scalable method for biallelic conditional gene knockouts.
Wed Mar 01 00:00:00 UTC 2017
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states.
eLife
Jang S,Choubey S,Furchtgott L,Zou LN,Doyle A,Menon V,Loew EB,Krostag AR,Martinez RA,Madisen L,Levi BP,Ramanathan S
14981182 was used in immunocytochemistry to investigate the gene expression dynamics of early mouse embryonic stem cell differentiation
Wed Mar 15 00:00:00 UTC 2017
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states.
eLife
Jang S,Choubey S,Furchtgott L,Zou LN,Doyle A,Menon V,Loew EB,Krostag AR,Martinez RA,Madisen L,Levi BP,Ramanathan S
14981182 was used in immunocytochemistry to investigate the gene expression dynamics of early mouse embryonic stem cell differentiation
Wed Mar 15 00:00:00 UTC 2017
Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium.
PloS one
Kurtenbach S,Ding W,Goss GM,Hare JM,Goldstein BJ,Shehadeh LA
14-9811 was used in Immunohistochemistry to demonstrate that microRNAs are differentially expressed by either progenitor or progeny cells in the regenerating mouse olfactory epithelium.
Tue Nov 28 00:00:00 UTC 2017
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Nature communications
Megaw R,Abu-Arafeh H,Jungnickel M,Mellough C,Gurniak C,Witke W,Zhang W,Khanna H,Mill P,Dhillon B,Wright AF,Lako M,Ffrench-Constant C
14-9811 was used in Immunofluorescence to reveal a role for RPGR in gelosin activation, without which abnormalities in actin polymerisation in the photoreceptor connecting cilia cause rhodopsin mislocalisation and retinal degeneration in XLRP.
Wed Aug 16 00:00:00 UTC 2017
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Development (Cambridge, England)
Alexandrova S,Kalkan T,Humphreys P,Riddell A,Scognamiglio R,Trumpp A,Nichols J
14-9811 was used in Immunohistochemistry to examine the role of cellular heterogeneity in the incorporation of pluripotent cells into host embryos.
Fri Jan 01 00:00:00 UTC 2016
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Development (Cambridge, England)
Alexandrova S,Kalkan T,Humphreys P,Riddell A,Scognamiglio R,Trumpp A,Nichols J
14-9811 was used in Immunohistochemistry to examine the role of cellular heterogeneity in the incorporation of pluripotent cells into host embryos.
Fri Jan 01 00:00:00 UTC 2016
SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1).
Development (Cambridge, England)
Yamamizu K,Schlessinger D,Ko MS
14-9811 was used in Western Blotting to explore a molecular cascade that is potentially an early step in the programming of ESC differentiation.
Sat Nov 01 00:00:00 UTC 2014
SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1).
Development (Cambridge, England)
Yamamizu K,Schlessinger D,Ko MS
14-9811 was used in Western Blotting to explore a molecular cascade that is potentially an early step in the programming of ESC differentiation.
Sat Nov 01 00:00:00 UTC 2014
