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Proteintech
SOX8 Polyclonal Antibody
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Product Details
20627-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SOX8 Fusion Protein Ag14556 (298-446 aa encoded by BC031797)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EPGQAYGGA YFHAGASPVW AHKSAPSASA SPTETGPPRP HIKTEQPSPG HYGDQPRGSP DYGSCSGQSS ATPAAPAGPF AGSQGDYGDL QASSYYGAYP GYAPGLYQYP CFHSPRRPYA SPLLNGLALP PAHSPTSHWD QPVYTTLTRP (298-446 aa encoded by BC031797)
Target Information
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 8; SRY box 8; SRY-box containing gene 8; Transcription factor SOX-8
Gene Aliases: Sox-8; SOX8
UniProt ID: (Human) P57073, (Mouse) Q04886
Entrez Gene ID: (Human) 30812, (Mouse) 20681
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor binding
protein heterodimerization activity
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
osteoblast differentiation
in utero embryonic development
neural crest cell migration
transcription, DNA-templated
signal transduction
spermatogenesis
peripheral nervous system development
male gonad development
regulation of hormone levels
positive regulation of gliogenesis
positive regulation of osteoblast proliferation
skeletal muscle cell differentiation
negative regulation of apoptotic process
cell fate commitment
fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of photoreceptor cell differentiation
cell maturation
enteric nervous system development
oligodendrocyte differentiation
Sertoli cell development
astrocyte fate commitment
retina development in camera-type eye
retinal rod cell differentiation
adipose tissue development
morphogenesis of a branching epithelium
renal vesicle induction
ureter morphogenesis
metanephric nephron tubule formation
positive regulation of kidney development
positive regulation of branching involved in ureteric bud morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of gene expression
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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