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          • Primary Antibodies ›
          • SOX8/SOX9/SOX17/SOX18 Antibodies

          Invitrogen

          SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          View all (2) SOX8/SOX9/SOX17/SOX18 antibodies

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          Cite SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          • Antibody Testing Data (4)
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 4

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          SOX8/SOX9/SOX17/SOX18 Antibody (PA5-36315) in IHC (P)

          Immunohistochemistry analysis of SOX8/SOX9/SOX17/SOX18 in paraffin-embedded human colorectal carcinoma tissue. Samples were incubated with SOX8/SOX9/SOX17/SOX18 polyclonal antibody (Product # PA5-36315) at a dilution of 1:50. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX8/SOX9/SOX17/SOX18 Antibody in Western Blot (WB)
          SOX8/SOX9/SOX17/SOX18 Antibody in Western Blot (WB)

          Product Details

          PA5-36315

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to amino acids 120-170 of human Sox8
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2

          Contains

          0.05% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2553470

          Product Specific Information

          This antibody detects endogenous protein at a molecular weight of 47 kDa.

          Purity is >95% by SDS-PAGE.

          Target Information

          Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: mSox9; ragged; SRY (sex determining region Y)-box 17; SRY (sex determining region Y)-box 18; SRY (sex determining region Y)-box 8; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 17; SRY box 18; SRY box 8; SRY box 9; SRY-box containing gene 17; SRY-box containing gene 18; SRY-box containing gene 8; SRY-box containing gene 9; Sry-related HMG-box gene 18; SRY-related HMG-box transcription factor SOX17; SRY-related HMG-box, gene 9; Transcription factor SOX-17; Transcription factor SOX-18; Transcription factor SOX-8; Transcription factor SOX-9

          View more View less

          Gene Aliases: 2010306G03Rik; AI385749; AV220920; CMD1; CMPD1; HLTRS; HLTS; mKIAA4243; Ra; Ragl; Sox-17; Sox-18; Sox-8; Sox-9; SOX17; SOX18; SOX8; SOX9; SRA1; SRXX2; SRXY10; VUR3

          View more View less

          UniProt ID: (Human) Q9H6I2, (Human) P35713, (Human) P57073, (Human) P48436, (Mouse) Q61473, (Mouse) P43680, (Mouse) Q04886, (Rat) F1LYL9, (Mouse) Q04887

          View more View less

          Entrez Gene ID: (Human) 64321, (Human) 54345, (Human) 30812, (Human) 6662, (Mouse) 20671, (Rat) 312936, (Rat) 311723, (Mouse) 20672, (Mouse) 20681, (Rat) 302993, (Rat) 140586, (Mouse) 20682

          View more View less

          Function(s)
          transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding beta-catenin binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding core promoter sequence-specific DNA binding enhancer sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein kinase activity protein kinase A catalytic subunit binding enhancer binding bHLH transcription factor binding pre-mRNA intronic binding molecular_function transcription regulatory region sequence-specific DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis vasculogenesis endoderm formation inner cell mass cellular morphogenesis heart looping cardiogenic plate morphogenesis embryonic heart tube morphogenesis outflow tract morphogenesis negative regulation of Wnt signaling pathway involved in heart development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter spermatogenesis gastrulation endoderm development endodermal cell fate determination positive regulation of gene expression Wnt signaling pathway rostrocaudal neural tube patterning signal transduction involved in regulation of gene expression negative regulation of Wnt signaling pathway negative regulation of cell growth protein destabilization embryonic heart tube development cell migration involved in gastrulation regulation of mesodermal cell fate specification negative regulation of mesodermal cell fate specification mRNA transcription from RNA polymerase II promoter regulation of cell differentiation positive regulation of cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development embryonic organ development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development stem cell differentiation stem cell fate specification protein stabilization canonical Wnt signaling pathway endocardium formation regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification cardiac cell fate determination endocardial cell differentiation common bile duct development gall bladder development endodermal digestive tract morphogenesis renal system development regulation of stem cell proliferation negative regulation of canonical Wnt signaling pathway regulation of stem cell division regulation of cardiac cell fate specification heart formation skeletal system development cartilage condensation ossification branching involved in ureteric bud morphogenesis cell fate specification epithelial to mesenchymal transition tissue homeostasis positive regulation of protein phosphorylation hair follicle development positive regulation of mesenchymal cell proliferation chondrocyte development negative regulation of immune system process heart valve development heart valve morphogenesis heart valve formation endocardial cushion morphogenesis chondrocyte differentiation involved in endochondral bone morphogenesis chondrocyte hypertrophy nucleosome assembly chromatin remodeling regulation of transcription from RNA polymerase II promoter protein complex assembly protein phosphorylation cytoskeleton organization signal transduction epidermal growth factor receptor signaling pathway heart development positive regulation of cell proliferation negative regulation of cell proliferation male gonad development regulation of cell cycle process negative regulation of gene expression positive regulation of epithelial cell migration neural crest cell development positive regulation of phosphatidylinositol 3-kinase signaling single organismal cell-cell adhesion male germ-line sex determination cAMP-mediated signaling cell differentiation regulation of cell adhesion extracellular matrix organization male sex determination negative regulation of ossification negative regulation of bone mineralization prostate gland development negative regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation mammary gland development notochord development otic vesicle formation endocrine pancreas development negative regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation lacrimal gland development protein localization to nucleus somatic stem cell population maintenance intrahepatic bile duct development regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process protein kinase B signaling cell fate commitment negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated negative regulation of photoreceptor cell differentiation oligodendrocyte differentiation homeostasis of number of cells within a tissue positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation cartilage development Sertoli cell differentiation Sertoli cell development astrocyte fate commitment retina development in camera-type eye limb bud formation retinal rod cell differentiation endochondral bone morphogenesis epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation prostate gland morphogenesis epithelial cell proliferation involved in prostatic bud elongation bronchus cartilage development trachea cartilage development intestinal epithelial structure maintenance regulation of cell proliferation involved in tissue homeostasis positive regulation of cartilage development regulation of branching involved in lung morphogenesis morphogenesis of a branching epithelium lung smooth muscle development negative regulation of biomineral tissue development ERK1 and ERK2 cascade Harderian gland development cellular response to mechanical stimulus cellular response to retinoic acid cellular response to interleukin-1 cellular response to epidermal growth factor stimulus cellular response to heparin cellular response to transforming growth factor beta stimulus renal vesicle induction ureter development ureter urothelium development ureter smooth muscle cell differentiation ureter morphogenesis metanephric nephron tubule formation cochlea morphogenesis positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis positive regulation of extracellular matrix assembly positive regulation of male gonad development positive regulation of cell proliferation involved in heart morphogenesis positive regulation of mesenchymal stem cell differentiation regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell apoptotic process osteoblast differentiation in utero embryonic development neural crest cell migration peripheral nervous system development regulation of hormone levels positive regulation of gliogenesis positive regulation of osteoblast proliferation skeletal muscle cell differentiation fat cell differentiation cell maturation enteric nervous system development adipose tissue development Notch signaling pathway vasculature development lymphangiogenesis hair cycle process blood vessel endothelial cell migration lymphatic endothelial cell differentiation establishment of endothelial barrier biological_process blood vessel development lymph vessel development
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