Proteintech

SP1 Monoclonal Antibody (4G3H3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

66508-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:175-1:700
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:350
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4G3H3

Immunogen

SP1 Fusion Protein Ag16720 (437-785 aa encoded by BC062539)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NLQLQAVPN SGPIIIRTPT VGPNGQVSWQ TLQLQNLQVQ NPQAQTITLA PMQGVSLGQT SSSNTTLTPI ASAASIPAGT VTVNAAQLSS MPGLQTINLS ALGTSGIQVH PIQGLPLAIA NAPGDHGAQL GLHGAGGDGI HDDTAGGEEG ENSPDAQPQA GRRTRREACT CPYCKDSEGR GSGDPGKKKQ HICHIQGCGK VYGKTSHLRA HLRWHTGERP FMCTWSYCGK RFTRSDELQR HKRTHTGEKK FACPECPKRF MRSDHLSKHI KTHQNKKGGP GVALSVGTLP LDSGAGSEGS GTATPSALIT TNMVAMEAIC PEGIARLANS GINVMQVADL QSINISGNGF (437-785 aa encoded by BC062539)

Target Information

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HGNC:11205; Specificity protein 1; trans-acting transcription factor 1; Transcription factor Sp1

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Gene Aliases: 1110003E12Rik; AA450830; AI845540; SP1; Sp1-1; TSFP1

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UniProt ID: (Human) P08047, (Mouse) O89090, (Rat) Q01714

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Entrez Gene ID: (Human) 6667, (Mouse) 20683, (Rat) 24790

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter sequence-specific DNA binding RNA polymerase II repressing transcription factor binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding transcription factor binding histone acetyltransferase binding protein homodimerization activity histone deacetylase binding bHLH transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding HMG box domain binding RNA polymerase II core promoter sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding nucleic acid binding enhancer binding RNA polymerase II transcription factor activity, sequence-specific DNA binding
Process(es)
ossification in utero embryonic development trophectodermal cell differentiation liver development embryonic placenta development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter megakaryocyte differentiation lung development enucleate erythrocyte differentiation positive regulation by host of viral transcription positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process embryonic camera-type eye morphogenesis embryonic skeletal system development embryonic process involved in female pregnancy definitive hemopoiesis viral process snRNA transcription from RNA polymerase II promoter regulation of phenotypic switching by transcription from RNA polymerase II promoter positive regulation of hydrogen sulfide biosynthetic process
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