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Invitrogen
SP3 Monoclonal Antibody (4E5)
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Product Details
MA5-20003
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4E5
Immunogen
SP3 (NP_003102, 287 a.a. ~ 430 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608151
Product Specific Information
Peptide Sequence: TAGINADGHL INTGQAMDSS DNSERTGERV SPDINETNTD TDLFVPTSSS SQLPVTIDST GILQQNTNSL TTSSGQVHSS DLQGNYIQSP VSEETQAQNI QVSTAQPVVQ HLQLQESQQP TSQAQIVQGI TPQTIHGVQA SGQN*
Target Information
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686O1631; GC-binding transcription factor Sp3; specificity protein 3; SPR-1; SPR-2; SPR1; trans-acting transcription factor 3; Transcription factor Sp3
Gene Aliases: D130027J01Rik; SP3; SPR2
UniProt ID: (Human) Q02447, (Mouse) O70494
Entrez Gene ID: (Human) 6670, (Mouse) 20687, (Rat) 367846
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
metal ion binding
nucleic acid binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
ossification
in utero embryonic development
natural killer cell differentiation
trophectodermal cell differentiation
liver development
embryonic placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
B cell differentiation
T cell differentiation
erythrocyte differentiation
megakaryocyte differentiation
monocyte differentiation
lung development
granulocyte differentiation
enucleate erythrocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
embryonic camera-type eye morphogenesis
embryonic skeletal system development
embryonic process involved in female pregnancy
definitive hemopoiesis
protein sumoylation
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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