Proteintech

SPAG4L Polyclonal Antibody

SPAG4L Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

SPAG4L Antibody (17495-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed PC-3 cells using 17495-1-AP (SPAG4L antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

17495-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 9 publications 9 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SPAG4L Fusion Protein Ag11629 (1-379 aa encoded by BC026118)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPRSSRSPG DPGALLEDVA HNPRPRRIAQ RGRNTSRMAE DTSPNMNDNI LLPVRNNDQA LGLTQCMLGC VSWFTCFACS LRTQAQQVLF NTCRCKLLCQ KLMEKTGILL LCAFGFWMFS IHLPSKMKVW QDDSINGPLQ SLRLYQEKVR HHSGEIQDLR GSMNQLIAKL QEMEAMSDEQ KMAQKIMKMI HGDYIEKPDF ALKSIGASID FEHTSVTYNH EKAHSYWNWI QLWNYAQPPD VILEPNVTPG NCWAFEGDRG QVTIQLAQKV YLSNLTLQHI PKTISLSGSL DTAPKDFVIY GMEGSPKEEV FLGAFQFQPE NIIQMFPLQN QPARAFSAVK VKISSNWGNP GFTCLYRVRV HGSVAPPREQ PHQNPYPKRD (1-379 aa encoded by BC026118)

Target Information

The function of this protein remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome.

Reproductive sciences (Thousand Oaks, Calif.)

Xiang M,Wang Y,Wang K,Kong S,Lu M,Zhang J,Duan Z,Zha X,Shi X,Wang F,Cao Y,Zhu F

Tue Feb 01 00:00:00 UTC 2022

Nuclear Membrane Protein SUN5 Is Highly Expressed and Promotes Proliferation and Migration in Colorectal Cancer by Regulating the ERK Pathway.

Cancers

Song X,Li R,Liu G,Huang L,Li P,Feng W,Gao Q,Xing X

Mon Oct 31 00:00:00 UTC 2022

Nuclear Membrane Protein SUN5 Is Highly Expressed and Promotes Proliferation and Migration in Colorectal Cancer by Regulating the ERK Pathway.

Cancers

Song X,Li R,Liu G,Huang L,Li P,Feng W,Gao Q,Xing X

Mon Oct 31 00:00:00 UTC 2022

SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice.

Frontiers in cell and developmental biology

Zhang Y,Yang L,Huang L,Liu G,Nie X,Zhang X,Xing X

Sat Jul 17 00:00:00 UTC 2021

SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice.

Frontiers in cell and developmental biology

Zhang Y,Yang L,Huang L,Liu G,Nie X,Zhang X,Xing X

Sat Jul 17 00:00:00 UTC 2021

Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa.

International journal of molecular sciences

Cazin C,Boumerdassi Y,Martinez G,Fourati Ben Mustapha S,Whitfield M,Coutton C,Thierry-Mieg N,Di Pizio P,Rives N,Arnoult C,Touré A,Ray PF,Zouari R,Sifer C,Kherraf ZE

Mon Feb 22 00:00:00 UTC 2021

The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.

Nature communications

Zhang Y,Liu C,Wu B,Li L,Li W,Yuan L

Fri Aug 13 00:00:00 UTC 2021

Biallelic mutations in PMFBP1 cause acephalic spermatozoa.

Clinical genetics

Sha YW,Wang X,Xu X,Ding L,Liu WS,Li P,Su ZY,Chen J,Mei LB,Zheng LK,Wang HL,Kong SB,You M,Wu JF

Fri Feb 01 00:00:00 UTC 2019

Biallelic mutations in PMFBP1 cause acephalic spermatozoa.

Clinical genetics

Sha YW,Wang X,Xu X,Ding L,Liu WS,Li P,Su ZY,Chen J,Mei LB,Zheng LK,Wang HL,Kong SB,You M,Wu JF

Fri Feb 01 00:00:00 UTC 2019

Biallelic mutations in PMFBP1 cause acephalic spermatozoa.

Clinical genetics

Sha YW,Wang X,Xu X,Ding L,Liu WS,Li P,Su ZY,Chen J,Mei LB,Zheng LK,Wang HL,Kong SB,You M,Wu JF

Fri Feb 01 00:00:00 UTC 2019

Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome.

American journal of human genetics

Zhu F,Liu C,Wang F,Yang X,Zhang J,Wu H,Zhang Z,He X,Zhang Z,Zhou P,Wei Z,Shang Y,Wang L,Zhang R,Ouyang YC,Sun QY,Cao Y,Li W

Thu Aug 02 00:00:00 UTC 2018

Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome.

American journal of human genetics

Zhu F,Liu C,Wang F,Yang X,Zhang J,Wu H,Zhang Z,He X,Zhang Z,Zhou P,Wei Z,Shang Y,Wang L,Zhang R,Ouyang YC,Sun QY,Cao Y,Li W

Thu Aug 02 00:00:00 UTC 2018

Patients with acephalic spermatozoa syndrome linked to SUN5 mutations have a favorable pregnancy outcome from ICSI.

Human reproduction (Oxford, England)

Fang J,Zhang J,Zhu F,Yang X,Cui Y,Liu J

Thu Mar 01 00:00:00 UTC 2018

Patients with acephalic spermatozoa syndrome linked to SUN5 mutations have a favorable pregnancy outcome from ICSI.

Human reproduction (Oxford, England)

Fang J,Zhang J,Zhu F,Yang X,Cui Y,Liu J

Thu Mar 01 00:00:00 UTC 2018

Essential role for SUN5 in anchoring sperm head to the tail.

eLife

Shang Y,Zhu F,Wang L,Ouyang YC,Dong MZ,Liu C,Zhao H,Cui X,Ma D,Zhang Z,Yang X,Guo Y,Liu F,Yuan L,Gao F,Guo X,Sun QY,Cao Y,Li W

Mon Sep 25 00:00:00 UTC 2017

Essential role for SUN5 in anchoring sperm head to the tail.

eLife

Shang Y,Zhu F,Wang L,Ouyang YC,Dong MZ,Liu C,Zhao H,Cui X,Ma D,Zhang Z,Yang X,Guo Y,Liu F,Yuan L,Gao F,Guo X,Sun QY,Cao Y,Li W

Mon Sep 25 00:00:00 UTC 2017

Essential role for SUN5 in anchoring sperm head to the tail.

eLife

Shang Y,Zhu F,Wang L,Ouyang YC,Dong MZ,Liu C,Zhao H,Cui X,Ma D,Zhang Z,Yang X,Guo Y,Liu F,Yuan L,Gao F,Guo X,Sun QY,Cao Y,Li W

Mon Sep 25 00:00:00 UTC 2017

Essential role for SUN5 in anchoring sperm head to the tail.

eLife

Shang Y,Zhu F,Wang L,Ouyang YC,Dong MZ,Liu C,Zhao H,Cui X,Ma D,Zhang Z,Yang X,Guo Y,Liu F,Yuan L,Gao F,Guo X,Sun QY,Cao Y,Li W

Mon Sep 25 00:00:00 UTC 2017

Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome.

American journal of human genetics

Zhu F,Wang F,Yang X,Zhang J,Wu H,Zhang Z,Zhang Z,He X,Zhou P,Wei Z,Gecz J,Cao Y

Thu Oct 06 00:00:00 UTC 2016

Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome.

American journal of human genetics

Zhu F,Wang F,Yang X,Zhang J,Wu H,Zhang Z,Zhang Z,He X,Zhou P,Wei Z,Gecz J,Cao Y

Thu Oct 06 00:00:00 UTC 2016

Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.

PloS one

Yassine S,Escoffier J,Abi Nahed R,Pierre V,Karaouzene T,Ray PF,Arnoult C

Thu Feb 04 00:00:00 UTC 2016

Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.

PloS one

Yassine S,Escoffier J,Abi Nahed R,Pierre V,Karaouzene T,Ray PF,Arnoult C

Thu Feb 04 00:00:00 UTC 2016

Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.

PloS one

Yassine S,Escoffier J,Abi Nahed R,Pierre V,Karaouzene T,Ray PF,Arnoult C

Thu Feb 04 00:00:00 UTC 2016

Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.

PloS one

Yassine S,Escoffier J,Abi Nahed R,Pierre V,Karaouzene T,Ray PF,Arnoult C

Thu Feb 04 00:00:00 UTC 2016

SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.

DNA and cell biology

Jiang XZ,Yang MG,Huang LH,Li CQ,Xing XW

Tue Nov 01 00:00:00 UTC 2011

SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.

DNA and cell biology

Jiang XZ,Yang MG,Huang LH,Li CQ,Xing XW

Tue Nov 01 00:00:00 UTC 2011

SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.

DNA and cell biology

Jiang XZ,Yang MG,Huang LH,Li CQ,Xing XW

Tue Nov 01 00:00:00 UTC 2011

SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.

DNA and cell biology

Jiang XZ,Yang MG,Huang LH,Li CQ,Xing XW

Tue Nov 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: Sad1 and UNC84 domain-containing protein 5; Sperm-associated antigen 4-like protein; SUN domain-containing protein 5; testis and spermatogenesis related gene 4; Testis and spermatogenesis-related gene 4 protein

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Gene Aliases: 1700021O15Rik; dJ726C3.1; SPAG4L; SPAG4L-2; SRG4; SUN5; TSARG4

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UniProt ID: (Human) Q8TC36, (Mouse) Q9DA32

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Entrez Gene ID: (Human) 140732, (Mouse) 76407

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Function(s)

molecular_function

Process(es)

nuclear envelope organization spermatogenesis cytoskeletal anchoring at nuclear membrane

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SPAG4L Polyclonal Antibody

SPAG4L Antibody (17495-1-AP) in ICC/IF

Product Details

17495-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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