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Bioss
SPANX Polyclonal Antibody
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Product Details
BS-7012R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SPANXA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer-testis-associated protein CTp11; Cancer/testis antigen 11.1; Cancer/testis antigen 11.2; Cancer/testis antigen 11.3; Cancer/testis antigen 11.4; cancer/testis antigen family 11, member 2; cancer/testis antigen family 11, member 3; cancer/testis antigen family 11, member 4; Cancer/testis-associated protein CTp11; cancer/testis-associated protein of 11 kD; CT11.1; CT11.2; CT11.3; CT11.4; Nuclear-associated protein SPAN-Xa; Nuclear-associated protein SPAN-Xb; Nuclear-associated protein SPAN-Xc; Nuclear-associated protein SPAN-Xd; nuclear-associated protein SPAN-Xe; nuclear-associated protein SPAN-Xf; SPAN-X; SPAN-Xc protein; SPANX family member A; SPANX family member B/F; SPANX family member B1; SPANX family member C; SPANX family member D; SPANX family member F1; SPANX family, member A2; SPANX family, member B1; SPANX family, member B2; SPANX family, member C; SPANX family, member D; SPANX family, member E; SPANX family, member F1; SPANX family, member F2; SPANX-B; SPANX-C; SPANX-D; Sperm protein associated with the nucleus on the X chromosome A; sperm protein associated with the nucleus on the X chromosome B/F; Sperm protein associated with the nucleus on the X chromosome B1; Sperm protein associated with the nucleus on the X chromosome C; Sperm protein associated with the nucleus on the X chromosome D; sperm protein associated with the nucleus, X chromosome, family member A2; sperm protein associated with the nucleus, X chromosome, family member B1; sperm protein associated with the nucleus, X chromosome, family member C; sperm protein associated with the nucleus, X chromosome, family member D; sperm protein associated with the nucleus, X chromosome, family member E
Gene Aliases: B1; C; CT11.1; CT11.2; CT11.3; CT11.4; CTp11; dJ171K16.1; SPANX; SPANX-A; SPANX-B; SPANX-C; SPANX-D; SPANX-E; SPANXA; SPANXA1; SPANXA2; SPANXB; SPANXB1; SPANXB2; SPANXC; SPANXD; SPANXE; SPANXF1; SPANXF2
UniProt ID: (Human) Q9NS26, (Human) Q9NS25, (Human) Q9NY87, (Human) Q9BXN6
Entrez Gene ID: (Human) 728712, (Human) 728695, (Human) 64663, (Human) 64648
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