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Abnova
SPDEF Monoclonal Antibody (4A5)
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Product Details
H00025803-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
4A5
Immunogen
SPDEF (NP_036523, 92 a.a. approximately 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: QCPVIDSQAP AGSLDLVPGG LTLEEHSLEQ VQSMVVGEVL KDIETACKLL NITADPMDWS PSNVQKWLLW TEHQYRLPPM GKAFQELAGK ELCAMSEEQF RQRSPLGGD
Target Information
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; SAM pointed domain-containing Ets transcription factor
Gene Aliases: bA375E1.3; PDEF; PSE; SPDEF
UniProt ID: (Human) O95238
Entrez Gene ID: (Human) 25803
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
negative regulation of cell fate commitment
positive regulation of cell fate commitment
cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
lung goblet cell differentiation
intestinal epithelial cell development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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